Cited 7 times in
Performance of REBA MTB-XDR to detect extensively drug-resistant tuberculosis in an intermediate-burden country
DC Field | Value | Language |
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dc.contributor.author | 이영석 | - |
dc.date.accessioned | 2016-02-04T11:12:58Z | - |
dc.date.available | 2016-02-04T11:12:58Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1341-321X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139924 | - |
dc.description.abstract | Extensively drug-resistant tuberculosis (XDR-TB) is a serious worldwide problem. The REBA MTB-XDR (REBA-XDR) was recently developed in Korea to detect resistance to ofloxacin, kanamycin, and streptomycin. The aim of this study is to evaluate the diagnostic accuracy of the REBA-XDR. We prospectively enrolled 104 patients with acid-fast bacilli smear-positive specimens between July 2010 and January 2013. Performance characteristics were compared between REBA-XDR and conventional drug-susceptibility testing. The sensitivity values of REBA-XDR for detecting resistance to ofloxacin, kanamycin, and streptomycin were 66.7%, 90.9%, and 60.0%, and the specificity values were 93.3%, 93.5%, and 85.4%, respectively. The positive predictive values were 62.5%, 62.5%, and 40.9%, and the negative predictive values were 94.3%, 98.9%, and 92.7%, respectively. Accuracy was 89.4%, 93.3%, and 81.7%, respectively. REBA-XDR seems to be a useful kit for "ruling in" XDR-TB in intermediate-burden countries, and especially useful for detecting kanamycin resistance. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 346~354 | - |
dc.relation.isPartOf | JOURNAL OF INFECTION AND CHEMOTHERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anti-Bacterial Agents/pharmacology* | - |
dc.subject.MESH | Drug Resistance, Multiple, Bacterial | - |
dc.subject.MESH | Extensively Drug-Resistant Tuberculosis/diagnosis | - |
dc.subject.MESH | Extensively Drug-Resistant Tuberculosis/drug therapy* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genes, MDR* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Isoniazid/pharmacology | - |
dc.subject.MESH | Kanamycin/pharmacology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microbial Sensitivity Tests/methods | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mycobacterium tuberculosis/drug effects* | - |
dc.subject.MESH | Mycobacterium tuberculosis/genetics* | - |
dc.subject.MESH | Ofloxacin/pharmacology | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Rifampin/pharmacology | - |
dc.subject.MESH | Sputum/microbiology | - |
dc.subject.MESH | Streptomycin/pharmacology | - |
dc.title | Performance of REBA MTB-XDR to detect extensively drug-resistant tuberculosis in an intermediate-burden country | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Young Seok Lee | - |
dc.contributor.googleauthor | Mi Ran Kang | - |
dc.contributor.googleauthor | Hoon Jung | - |
dc.contributor.googleauthor | Sang Bong Choi | - |
dc.contributor.googleauthor | Kyung Wook Jo | - |
dc.contributor.googleauthor | Tae Sun Shim | - |
dc.identifier.doi | 10.1016/j.jiac.2014.12.009 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02956 | - |
dc.relation.journalcode | J01453 | - |
dc.identifier.eissn | 1437-7780 | - |
dc.identifier.pmid | 25634305 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1341321X15000057 | - |
dc.subject.keyword | Extensively drug-resistant tuberculosis | - |
dc.subject.keyword | Kanamycin | - |
dc.subject.keyword | Molecular probes | - |
dc.subject.keyword | Nucleic acid hybridization | - |
dc.subject.keyword | Ofloxacin | - |
dc.contributor.alternativeName | Lee, Young Seok | - |
dc.contributor.affiliatedAuthor | Lee, Young Seok | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 21 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 346 | - |
dc.citation.endPage | 354 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INFECTION AND CHEMOTHERAPY, Vol.21(5) : 346-354, 2015 | - |
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