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Prognostic factors for cases with no extracranial metastasis in whom brain metastasis is detected after resection of non-small cell lung cancer

DC Field Value Language
dc.contributor.author김대준-
dc.contributor.author이진구-
dc.contributor.author이창영-
dc.contributor.author정경영-
dc.date.accessioned2016-02-04T11:12:48Z-
dc.date.available2016-02-04T11:12:48Z-
dc.date.issued2015-
dc.identifier.issn0169-5002-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139918-
dc.description.abstractOBJECTIVES: This study aimed to determine prognostic factors associated with postrecurrence survival in cases with postoperative brain metastasis but with no extracranial metastasis in non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: Between 1992 and 2012, a total of 2832 patients underwent surgical resection for NSCLC. Among those, 86 patients had postoperative brain metastasis as the initial recurrence. Those patients were retrospectively reviewed. RESULTS: The median follow-up time after the initial lung resection was 24.0 months (range, 2.0-126.0 months). The median overall survival after initial lung cancer resection was 25.0 months and the median overall postrecurrence survival was 11 months. An initial lesion of adenocarcinoma (hazard ratio, 0.548; 95% confidence interval, 0.318 to 0.946; p=0.031), non-pneumonectomy, and a disease-free interval longer than 10.0 months (hazard ratio, 0.565; 95% confidence interval, 0.321-0.995; p=0.048) from the initial lung resection to the diagnosis of brain metastasis positively related to a good postrecurrence survival. Solitary brain metastasis and a size of less than 3 cm for the largest brain lesion were also positive factors for postrecurrence survival. Systemic chemotherapy for brain metastasis (hazard ratio, 0.356; 95% confidence interval, 0.189-0.670; p=0.001) and local treatment of surgery and/or stereotactic radiosurgery (SRS) for brain lesions (hazard ratio, 0.321; 95% confidence interval, 0.138-0.747; p=0.008) were positive factors for better postrecurrence survival. CONCLUSION: In patients with brain metastasis after resection for NSCLC with no extracranial metastasis, adenocarcinoma histologic type, longer disease-free interval, systemic chemotherapy for brain metastasis and local treatment of surgery and/or SRS for brain metastasis are independent positive prognostic factors for postrecurrence survival.-
dc.description.statementOfResponsibilityopen-
dc.format.extent195~200-
dc.relation.isPartOfLUNG CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/pathology-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBrain/pathology*-
dc.subject.MESHBrain/radiation effects-
dc.subject.MESHBrain Neoplasms/pathology*-
dc.subject.MESHBrain Neoplasms/radiotherapy-
dc.subject.MESHBrain Neoplasms/secondary*-
dc.subject.MESHCarcinoma, Non-Small-Cell Lung/pathology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLung Neoplasms/pathology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local/pathology-
dc.subject.MESHPrognosis-
dc.subject.MESHRadiosurgery/methods-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.titlePrognostic factors for cases with no extracranial metastasis in whom brain metastasis is detected after resection of non-small cell lung cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic & Cardiovascular Surgery (흉부외과학)-
dc.contributor.googleauthorMi Kyung Bae-
dc.contributor.googleauthorWoo Sik Yu-
dc.contributor.googleauthorGo Eun Byun-
dc.contributor.googleauthorChang Young Lee-
dc.contributor.googleauthorJin Gu Lee-
dc.contributor.googleauthorDae Joon Kim-
dc.contributor.googleauthorKyung Young Chung-
dc.identifier.doi10.1016/j.lungcan.2015.02.013-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00368-
dc.contributor.localIdA03225-
dc.contributor.localIdA03245-
dc.contributor.localIdA03571-
dc.relation.journalcodeJ02174-
dc.identifier.eissn1872-8332-
dc.identifier.pmid25770646-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0169500215001208-
dc.subject.keywordBrain metastasis-
dc.subject.keywordNon-small cell lung cancer-
dc.subject.keywordPrognosis-
dc.subject.keywordRecurrence-
dc.contributor.alternativeNameKim, Dae Joon-
dc.contributor.alternativeNameLee, Jin Gu-
dc.contributor.alternativeNameLee, Chang Young-
dc.contributor.alternativeNameChung, Kyung Young-
dc.contributor.affiliatedAuthorKim, Dae Joon-
dc.contributor.affiliatedAuthorLee, Jin Gu-
dc.contributor.affiliatedAuthorLee, Chang Young-
dc.contributor.affiliatedAuthorChung, Kyung Young-
dc.rights.accessRightsnot free-
dc.citation.volume88-
dc.citation.number2-
dc.citation.startPage195-
dc.citation.endPage200-
dc.identifier.bibliographicCitationLUNG CANCER, Vol.88(2) : 195-200, 2015-
dc.identifier.rimsid48378-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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