Cited 16 times in
Prognostic factors for cases with no extracranial metastasis in whom brain metastasis is detected after resection of non-small cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | 김대준 | - |
dc.contributor.author | 이진구 | - |
dc.contributor.author | 이창영 | - |
dc.contributor.author | 정경영 | - |
dc.date.accessioned | 2016-02-04T11:12:48Z | - |
dc.date.available | 2016-02-04T11:12:48Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0169-5002 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139918 | - |
dc.description.abstract | OBJECTIVES: This study aimed to determine prognostic factors associated with postrecurrence survival in cases with postoperative brain metastasis but with no extracranial metastasis in non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: Between 1992 and 2012, a total of 2832 patients underwent surgical resection for NSCLC. Among those, 86 patients had postoperative brain metastasis as the initial recurrence. Those patients were retrospectively reviewed. RESULTS: The median follow-up time after the initial lung resection was 24.0 months (range, 2.0-126.0 months). The median overall survival after initial lung cancer resection was 25.0 months and the median overall postrecurrence survival was 11 months. An initial lesion of adenocarcinoma (hazard ratio, 0.548; 95% confidence interval, 0.318 to 0.946; p=0.031), non-pneumonectomy, and a disease-free interval longer than 10.0 months (hazard ratio, 0.565; 95% confidence interval, 0.321-0.995; p=0.048) from the initial lung resection to the diagnosis of brain metastasis positively related to a good postrecurrence survival. Solitary brain metastasis and a size of less than 3 cm for the largest brain lesion were also positive factors for postrecurrence survival. Systemic chemotherapy for brain metastasis (hazard ratio, 0.356; 95% confidence interval, 0.189-0.670; p=0.001) and local treatment of surgery and/or stereotactic radiosurgery (SRS) for brain lesions (hazard ratio, 0.321; 95% confidence interval, 0.138-0.747; p=0.008) were positive factors for better postrecurrence survival. CONCLUSION: In patients with brain metastasis after resection for NSCLC with no extracranial metastasis, adenocarcinoma histologic type, longer disease-free interval, systemic chemotherapy for brain metastasis and local treatment of surgery and/or SRS for brain metastasis are independent positive prognostic factors for postrecurrence survival. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 195~200 | - |
dc.relation.isPartOf | LUNG CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/pathology | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Brain/pathology* | - |
dc.subject.MESH | Brain/radiation effects | - |
dc.subject.MESH | Brain Neoplasms/pathology* | - |
dc.subject.MESH | Brain Neoplasms/radiotherapy | - |
dc.subject.MESH | Brain Neoplasms/secondary* | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lung Neoplasms/pathology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Recurrence, Local/pathology | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Radiosurgery/methods | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Prognostic factors for cases with no extracranial metastasis in whom brain metastasis is detected after resection of non-small cell lung cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic & Cardiovascular Surgery (흉부외과학) | - |
dc.contributor.googleauthor | Mi Kyung Bae | - |
dc.contributor.googleauthor | Woo Sik Yu | - |
dc.contributor.googleauthor | Go Eun Byun | - |
dc.contributor.googleauthor | Chang Young Lee | - |
dc.contributor.googleauthor | Jin Gu Lee | - |
dc.contributor.googleauthor | Dae Joon Kim | - |
dc.contributor.googleauthor | Kyung Young Chung | - |
dc.identifier.doi | 10.1016/j.lungcan.2015.02.013 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00368 | - |
dc.contributor.localId | A03225 | - |
dc.contributor.localId | A03245 | - |
dc.contributor.localId | A03571 | - |
dc.relation.journalcode | J02174 | - |
dc.identifier.eissn | 1872-8332 | - |
dc.identifier.pmid | 25770646 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0169500215001208 | - |
dc.subject.keyword | Brain metastasis | - |
dc.subject.keyword | Non-small cell lung cancer | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Recurrence | - |
dc.contributor.alternativeName | Kim, Dae Joon | - |
dc.contributor.alternativeName | Lee, Jin Gu | - |
dc.contributor.alternativeName | Lee, Chang Young | - |
dc.contributor.alternativeName | Chung, Kyung Young | - |
dc.contributor.affiliatedAuthor | Kim, Dae Joon | - |
dc.contributor.affiliatedAuthor | Lee, Jin Gu | - |
dc.contributor.affiliatedAuthor | Lee, Chang Young | - |
dc.contributor.affiliatedAuthor | Chung, Kyung Young | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 88 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 195 | - |
dc.citation.endPage | 200 | - |
dc.identifier.bibliographicCitation | LUNG CANCER, Vol.88(2) : 195-200, 2015 | - |
dc.identifier.rimsid | 48378 | - |
dc.type.rims | ART | - |
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