Cited 173 times in
Short- versus long-term dual antiplatelet therapy after drug-eluting stent implantation: an individual patient data pairwise and network meta-analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김병극 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 홍명기 | - |
dc.date.accessioned | 2016-02-04T11:12:39Z | - |
dc.date.available | 2016-02-04T11:12:39Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0735-1097 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139912 | - |
dc.description.abstract | BACKGROUND: Randomized controlled trials comparing short- (≤6 months) with long-term (≥1 year) dual antiplatelet therapy (DAPT) after drug-eluting stent(s) (DES) placement have been insufficiently powered to detect significant differences in the risk of major adverse cardiac events (MACE). OBJECTIVES: This study sought to compare clinical outcomes between short- (≤6 months) and long-term (1 year) DAPT and among 3 months, 6 months, and 1 year of DAPT post-DES placement by performing an individual patient data pairwise and network meta-analysis. METHODS: Randomized controlled trials comparing DAPT durations after DES placement were searched through the MEDLINE, EMBASE, and Cochrane databases and in international meeting proceedings. The primary study outcome was 1-year risk of MACE (cardiac death, myocardial infarction, or definite/probable stent thrombosis). RESULTS: Four trials including 8,180 randomized patients were identified. At 1-year follow-up, short-term DAPT was associated with similar rates of MACE (hazard ratio [HR]: 1.11; 95% confidence interval [CI]: 0.86 to 1.43; p = 0.44), but significantly lower rates of bleeding (HR: 0.66; 95% CI: 0.46 to 0.94; p = 0.03) versus prolonged DAPT. Comparable results were apparent in the landmark period between DAPT discontinuation and 1-year follow-up (for MACE: HR: 1.20; 95% CI: 0.77 to 1.89; p = 0.42) (for bleeding: HR: 0.44; 95% CI: 0.21 to 0.91; p = 0.03). There were no significant differences in 1-year rates of MACE among 3-month versus 1-year DAPT, 6-month versus 1-year DAPT, or 3-month versus 6-month DAPT. CONCLUSIONS: Compared with prolonged DAPT, short-term DAPT is associated with similar rates of MACE but lower rates of bleeding after DES placement. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1092~1102 | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | Drug-Eluting Stents* | - |
dc.subject.MESH | Graft Occlusion, Vascular/mortality | - |
dc.subject.MESH | Graft Occlusion, Vascular/prevention & control* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Myocardial Infarction/mortality | - |
dc.subject.MESH | Myocardial Infarction/prevention & control* | - |
dc.subject.MESH | Percutaneous Coronary Intervention* | - |
dc.subject.MESH | Platelet Aggregation Inhibitors/administration & dosage* | - |
dc.subject.MESH | Randomized Controlled Trials as Topic | - |
dc.title | Short- versus long-term dual antiplatelet therapy after drug-eluting stent implantation: an individual patient data pairwise and network meta-analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Tullio Palmerini | - |
dc.contributor.googleauthor | Diego Sangiorgi | - |
dc.contributor.googleauthor | MStat | - |
dc.contributor.googleauthor | Marco Valgimigli | - |
dc.contributor.googleauthor | Giuseppe Biondi Zoccai | - |
dc.contributor.googleauthor | Fausto Feres | - |
dc.contributor.googleauthor | Alexandre Abizaid | - |
dc.contributor.googleauthor | Ricardo A. Costa | - |
dc.contributor.googleauthor | Myeong Ki Hong | - |
dc.contributor.googleauthor | Byeong Keuk Kim | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Hyo Soo Kim | - |
dc.contributor.googleauthor | Kyung Woo Park | - |
dc.contributor.googleauthor | Andrea Mariani | - |
dc.contributor.googleauthor | Diego Della Riva | - |
dc.contributor.googleauthor | Philippe Genereux | - |
dc.contributor.googleauthor | Martin B. Leon | - |
dc.contributor.googleauthor | Deepak L. Bhatt | - |
dc.contributor.googleauthor | Umberto Bendetto | - |
dc.contributor.googleauthor | Claudio Rapezzi | - |
dc.contributor.googleauthor | Gregg W. Stone | - |
dc.identifier.doi | 10.1016/j.jacc.2014.12.046 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00493 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04391 | - |
dc.relation.journalcode | J01770 | - |
dc.identifier.eissn | 1558-3597 | - |
dc.identifier.pmid | 25790880 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0735109715001400 | - |
dc.subject.keyword | bleeding | - |
dc.subject.keyword | major adverse cardiac event(s) | - |
dc.subject.keyword | stent thrombosis | - |
dc.contributor.alternativeName | Kim, Byeong Keuk | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Hong, Myeong Ki | - |
dc.contributor.affiliatedAuthor | Kim, Byeong Keuk | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Hong, Myeong Ki | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 65 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1092 | - |
dc.citation.endPage | 1102 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol.65(11) : 1092-1102, 2015 | - |
dc.identifier.rimsid | 48373 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.