Cited 13 times in
Growth hormone treatment and risk of malignancy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김호성 | - |
dc.contributor.author | 채현욱 | - |
dc.date.accessioned | 2016-02-04T11:08:17Z | - |
dc.date.available | 2016-02-04T11:08:17Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1738-1061 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139749 | - |
dc.description.abstract | Growth hormone (GH) treatment has been increasingly widely used for children with GH deficiencies as the survival rate of pediatric patients with malignancies has increased. Both GH and insulin-like growth factor-I have mitogenic and antiapoptotic activity, prompting concern that GH treatment may be associated with tumor development. In this review, the authors examined the relationship between GH treatment and cancer risk in terms of de novo malignancy, recurrence, and secondary neoplasm. Although the results from numerous studies were not entirely consistent, this review of various clinical and epidemiological studies demonstrated that there is no clear evidence of a causal relationship between GH treatment and tumor development. Nonetheless, a small number of studies reported that childhood cancer survivors who receive GH treatment have a small increased risk of developing de novo cancer and secondary malignant neoplasm. Therefore, regular follow-ups and careful examination for development of cancer should be required in children who receive GH treatment. Continued surveillance for an extended period is essential for monitoring long-term safety. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 41~46 | - |
dc.language | Korean | - |
dc.publisher | 대한소아과학회 | - |
dc.relation.isPartOf | Korean Journal of Pediatrics | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Growth hormone treatment and risk of malignancy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학) | - |
dc.contributor.googleauthor | Hyun Wook Chae | - |
dc.contributor.googleauthor | Duk Hee Kim | - |
dc.contributor.googleauthor | Ho Seong Kim | - |
dc.identifier.doi | 10.3345/kjp.2015.58.2.41 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01184 | - |
dc.contributor.localId | A04026 | - |
dc.relation.journalcode | J02100 | - |
dc.identifier.eissn | 2092-7258 | - |
dc.identifier.pmid | 25774194 | - |
dc.subject.keyword | Growth hormone | - |
dc.subject.keyword | Malignancy insulin-like growth factor-I | - |
dc.subject.keyword | Neoplasms | - |
dc.subject.keyword | Recurrence | - |
dc.contributor.alternativeName | Kim, Ho Seong | - |
dc.contributor.alternativeName | Chae, Hyun Wook | - |
dc.contributor.affiliatedAuthor | Kim, Ho Seong | - |
dc.contributor.affiliatedAuthor | Chae, Hyun Wook | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 58 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 41 | - |
dc.citation.endPage | 46 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pediatrics, Vol.58(2) : 41-46, 2015 | - |
dc.identifier.rimsid | 52992 | - |
dc.type.rims | ART | - |
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