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Teriparatide therapy for bisphosphonate-related osteonecrosis of the jaw associated with dental implants

Authors
 Doh, Re-Mee  ;  Park, Hye-Jeong  ;  Rhee, Yumie  ;  Kim, Hyun Sil  ;  Huh, Jisun  ;  Park, Wonse 
Citation
 Implant Dentistry, Vol.24(2) : 222-226, 2015 
Journal Title
 Implant Dentistry 
ISSN
 1056-6163 
Issue Date
2015
Abstract
This report describes a case of teriparatide (TPTD) therapy for bisphosphonate (BP)-related osteonecrosis of the jaw induced after implant placement. A 75-year-old woman taking oral BP was referred with uncontrolled osteonecrosis of the mandible related to the implant placement. With conservative treatment, BP was suspended and daily subcutaneous injections of 20 μm/d TPTD were started. After 4 months of the therapy, fixture removal and sequestrectomy were performed. Histological analysis revealed necrotic lamellar bone and empty osteocytic lacunae. In contrast, multiple irregular reversal lines of the lamellar bone and active osteoblasts were noted adjacent to the lesion. There was a significant increase in serum C-terminal telopeptide cross-link of type 1 collagen and serum osteocalcin after commencement of the therapy. After 7 months off therapy, the serum levels of the 2 markers remained at a high level compared with the baseline.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00008505-201504000-00017&LSLINK=80&D=ovft
DOI
10.1097/ID.0000000000000232
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김현실(Kim, Hyun Sil) ORCID logo https://orcid.org/0000-0003-3614-1764
박원서(Park, Wonse) ORCID logo https://orcid.org/0000-0002-2081-1156
박혜정(Park, Hye Jeong)
이유미(Rhee, Yumie) ORCID logo https://orcid.org/0000-0003-4227-5638
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139691
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