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Cited 18 times in

Diastolic dysfunction is an independent predictor of cardiovascular events in incident dialysis patients with preserved systolic function

DC FieldValueLanguage
dc.contributor.author강신욱-
dc.contributor.author구향모-
dc.contributor.author김은진-
dc.contributor.author김찬호-
dc.contributor.author도화미-
dc.contributor.author류동열-
dc.contributor.author박정탁-
dc.contributor.author오형중-
dc.contributor.author유태현-
dc.contributor.author이미정-
dc.contributor.author한승혁-
dc.contributor.author한재현-
dc.contributor.author한지숙-
dc.date.accessioned2016-02-04T11:05:54Z-
dc.date.available2016-02-04T11:05:54Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139658-
dc.description.abstractBACKGROUND: Diastolic heart failure (HF), the prevalence of which is gradually increasing, is associated with cardiovascular (CV) morbidity and mortality in the general population and, more specifically, in patients with end-stage renal disease (ESRD). However, the impact of diastolic dysfunction on CV outcomes has not been studied in incident dialysis patients with preserved systolic function. METHODS: This prospective observational cohort study investigates the clinical consequence of diastolic dysfunction and the predictive power of diastolic echocardiographic parameters for CV events in 194 incident ESRD patients with normal or near normal systolic function, who started dialysis between July 2008 and August 2012. RESULTS: During a mean follow-up duration of 27.2 months, 57 patients (29.4%) experienced CV events. Compared to the CV event-free group, patients with CV events had a significantly higher left ventricular (LV) mass index, ratio of early mitral flow velocity (E) to early mitral annulus velocity (E') (E/E'), LA volume index (LAVI), deceleration time, and right ventricular systolic pressure, and a significantly lower LV ejection fraction and E'. In multivariate Cox proportional hazard analysis, E/E'>15 and LAVI>32 mL/m2 significantly predicted CV events (E/E'>15: hazard ratio [HR] = 5.40, 95% confidence interval [CI] = 2.73-10.70, P< .001; LAVI>32 mL/m2: HR = 5.56, 95% CI = 2.28-13.59, P< .001]. Kaplan-Meier analysis revealed that patients with both E/E'>15 and LAVI>32 mL/m2 had the worst CV outcomes. CONCLUSION: An increase in E/E' or LAVI is a significant risk factor for CV events in incident dialysis patients with preserved LV systolic function.-
dc.description.statementOfResponsibilityopen-
dc.format.extente0118694-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCardiovascular Diseases/diagnostic imaging-
dc.subject.MESHCardiovascular Diseases/mortality-
dc.subject.MESHCardiovascular Diseases/physiopathology*-
dc.subject.MESHDiastole/physiology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRenal Dialysis*-
dc.subject.MESHRisk Factors-
dc.subject.MESHSystole/physiology*-
dc.subject.MESHUltrasonography-
dc.titleDiastolic dysfunction is an independent predictor of cardiovascular events in incident dialysis patients with preserved systolic function-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJae Hyun Han-
dc.contributor.googleauthorJi Suk Han-
dc.contributor.googleauthorEun Jin Kim-
dc.contributor.googleauthorFa Mee Doh-
dc.contributor.googleauthorHyang Mo Koo-
dc.contributor.googleauthorChan Ho Kim-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorHyung Jung Oh-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorDong-Ryeol Ryu-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorShin-Wook Kang-
dc.identifier.doi10.1371/journal.pone.0118694-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00053-
dc.contributor.localIdA00203-
dc.contributor.localIdA01037-
dc.contributor.localIdA01315-
dc.contributor.localIdA01323-
dc.contributor.localIdA01654-
dc.contributor.localIdA02417-
dc.contributor.localIdA02526-
dc.contributor.localIdA04304-
dc.contributor.localIdA04320-
dc.contributor.localIdA04327-
dc.contributor.localIdA00823-
dc.contributor.localIdA02773-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid25739020-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKoo, Hyang Mo-
dc.contributor.alternativeNameKim, Eun Jin-
dc.contributor.alternativeNameKim, Chan Ho-
dc.contributor.alternativeNameDoh, Fa Mee-
dc.contributor.alternativeNameRyu, Dong Ryeol-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.alternativeNameOh, Hyung Jung-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameHan, Jae Hyun-
dc.contributor.alternativeNameHahn, Jee Sook-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorKoo, Hyang Mo-
dc.contributor.affiliatedAuthorKim, Chan Ho-
dc.contributor.affiliatedAuthorDoh, Fa Mee-
dc.contributor.affiliatedAuthorRyu, Dong Ryeol-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorOh, Hyung Jung-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorHan, Jae Hyun-
dc.contributor.affiliatedAuthorHahn, Jee Sook-
dc.contributor.affiliatedAuthorKim, Eun Jin-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.rights.accessRightsfree-
dc.citation.volume10-
dc.citation.number3-
dc.citation.startPagee0118694-
dc.identifier.bibliographicCitationPLOS ONE, Vol.10(3) : e0118694, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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