Cited 32 times in
Efficacy of a single dose of dexmedetomidine for cough suppression during anesthetic emergence: a randomized controlled trial
DC Field | Value | Language |
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dc.contributor.author | 최승호 | - |
dc.contributor.author | 강영란 | - |
dc.contributor.author | 심연희 | - |
dc.contributor.author | 이정수 | - |
dc.date.accessioned | 2016-02-04T11:04:52Z | - |
dc.date.available | 2016-02-04T11:04:52Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0832-610X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139620 | - |
dc.description.abstract | PURPOSE: Maintenance of a remifentanil infusion during anesthetic emergence has been reported to decrease the incidence of coughing and thereby help to ensure a smooth emergence. It may, however, cause respiratory depression and possibly delay emergence. The purpose of this study was to investigate the effect of a single dose of dexmedetomidine combined with a low-dose remifentanil infusion on cough suppression during emergence from general anesthesia. METHODS: American Society of Anesthesiologists physical status I-II adults undergoing elective thyroidectomy under sevoflurane anesthesia were recruited and randomly allocated to receive either dexmedetomidine 0.5 μg·kg(-1) iv (Group D, n = 70) or saline (Group S, n = 71), each combined with a low-dose remifentanil infusion ten minutes before the end of surgery. Coughing was assessed using a four-point scale. The respiratory rate (RR), heart rate (HR), and mean arterial pressure were also recorded. RESULTS: The incidence of coughing was lower in Group D than in Group S (64% vs 91%, respectively; mean difference 27%; 95% confidence interval [CI] 13 to 41; P < 0.001). The median cough grade at extubation was also lower in Group D. Mean arterial pressure and HR were elevated in Group S during tracheal extubation but were similar to baseline values in Group D. There was no difference in RR between the two groups throughout the study. A small delay in extubation was observed in Group D (3 minutes longer than Group S; 95% CI 2 to 4; P < 0.001). CONCLUSION: Compared with an infusion of low-dose remifentanil alone, the addition of a single dose (0.5 μg·kg(-1)) of dexmedetomidine during emergence from sevoflurane-remifentanil anesthesia was effective in attenuating coughing and hemodynamic changes and did not exacerbate respiratory depression after thyroid surgery. This trial was registered at Clinicaltrial.gov, identifier: NCT01774305. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 392~398 | - |
dc.relation.isPartOf | CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adrenergic alpha-2 Receptor Agonists/administration & dosage* | - |
dc.subject.MESH | Adrenergic alpha-2 Receptor Agonists/adverse effects | - |
dc.subject.MESH | Adrenergic alpha-2 Receptor Agonists/therapeutic use | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Airway Extubation | - |
dc.subject.MESH | Anesthesia Recovery Period | - |
dc.subject.MESH | Anesthesia, General/methods* | - |
dc.subject.MESH | Arterial Pressure/drug effects | - |
dc.subject.MESH | Cough/epidemiology | - |
dc.subject.MESH | Cough/etiology | - |
dc.subject.MESH | Cough/prevention & control* | - |
dc.subject.MESH | Dexmedetomidine/administration & dosage* | - |
dc.subject.MESH | Dexmedetomidine/adverse effects | - |
dc.subject.MESH | Dexmedetomidine/therapeutic use | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Heart Rate/drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Methyl Ethers/administration & dosage | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Piperidines/administration & dosage | - |
dc.subject.MESH | Thyroidectomy/methods | - |
dc.title | Efficacy of a single dose of dexmedetomidine for cough suppression during anesthetic emergence: a randomized controlled trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | Jeong Soo Lee | - |
dc.contributor.googleauthor | Seung Ho Choi | - |
dc.contributor.googleauthor | Young Ran Kang | - |
dc.contributor.googleauthor | Yunhee Kim | - |
dc.contributor.googleauthor | Yon Hee Shim | - |
dc.identifier.doi | 10.1007/s12630-014-0295-6 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00055 | - |
dc.contributor.localId | A02196 | - |
dc.contributor.localId | A03109 | - |
dc.contributor.localId | A04101 | - |
dc.relation.journalcode | J00426 | - |
dc.identifier.eissn | 1496-8975 | - |
dc.identifier.pmid | 25523837 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs12630-014-0295-6 | - |
dc.subject.keyword | Mean Arterial Pressure | - |
dc.subject.keyword | Sevoflurane | - |
dc.subject.keyword | Remifentanil | - |
dc.subject.keyword | Dexmedetomidine | - |
dc.subject.keyword | Tracheal Extubation | - |
dc.contributor.alternativeName | Choi, Seung Ho | - |
dc.contributor.alternativeName | Kang, Young Ran | - |
dc.contributor.alternativeName | Shim, Yon Hee | - |
dc.contributor.alternativeName | Lee, Jeong Soo | - |
dc.contributor.affiliatedAuthor | Kang, Young Ran | - |
dc.contributor.affiliatedAuthor | Shim, Yon Hee | - |
dc.contributor.affiliatedAuthor | Lee, Jeong Soo | - |
dc.contributor.affiliatedAuthor | Choi, Seung Ho | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 62 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 392 | - |
dc.citation.endPage | 398 | - |
dc.identifier.bibliographicCitation | CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE, Vol.62(4) : 392-398, 2015 | - |
dc.identifier.rimsid | 52363 | - |
dc.type.rims | ART | - |
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