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Genetic investigation of bisphosphonate-related osteonecrosis of jaw (BRONJ) via whole exome sequencing and bioinformatics

DC FieldValueLanguage
dc.contributor.author김지영-
dc.contributor.author김지환-
dc.contributor.author오윤수-
dc.contributor.author이재훈-
dc.contributor.author한동후-
dc.date.accessioned2016-02-04T11:04:38Z-
dc.date.available2016-02-04T11:04:38Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139611-
dc.description.abstractComplications associated with the use of bisphosphonate (BP) have risen over the years due to an increase in the prescription of BP. BP-related osteonecrosis of jaw (BRONJ), one of the complications linked to the consumption of BP, greatly affects patients with minor dental trauma, incurring a long healing period. While BRONJ afflicts only a minority of patients prescribed with BP, BRONJ is a multigenic disease affected both by environmental and genetic factors having a distinctive phenotype. This study aims to discover genetic biomarkers associated with BRONJ via whole exome sequencing (WES) followed by statistical analysis. Sixteen individuals who had been prescribed with bisphosphonate medication and diagnosed as BRONJ were chosen and each individual's saliva sample was collected for WES. 126 randomized subsamples from the GSK project representing 109 male and 17 female Koreans were used as a control data set. Fisher's exact test was carried out to assess the significance of genetic variants in BRONJ patients. Gene set enrichment analysis (GSEA) (DAVID Bioinformatics Resource 6.7) was used to perform a cluster analysis of variants found from Fisher's exact test. The results from this study suggest that BRONJ-inducing factors are genetically associated and BRONJ occurs due to the malfunctioning of post-translational modification in osteoclast leading to the impairment of cell morphology and adhesion.-
dc.description.statementOfResponsibilityopen-
dc.format.extente0118084-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHBisphosphonate-Associated Osteonecrosis of the Jaw/genetics*-
dc.subject.MESHExome/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHGenomics*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.titleGenetic investigation of bisphosphonate-related osteonecrosis of jaw (BRONJ) via whole exome sequencing and bioinformatics-
dc.typeArticle-
dc.contributor.collegeResearcher Institutes (부설 연구소)-
dc.contributor.departmentOral Science Research Center (구강과학연구소)-
dc.contributor.googleauthorJee-Hwan Kim-
dc.contributor.googleauthorYong Jae Ko-
dc.contributor.googleauthorJi-young Kim-
dc.contributor.googleauthorYoonsoo Oh-
dc.contributor.googleauthorJihye Hwang-
dc.contributor.googleauthorSangjin Han-
dc.contributor.googleauthorSanguk Kim-
dc.contributor.googleauthorJae-Hoon Lee-
dc.contributor.googleauthorDong-Hoo Han-
dc.identifier.doi10.1371/journal.pone.0118084-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01006-
dc.contributor.localIdA02392-
dc.contributor.localIdA04277-
dc.contributor.localIdA03091-
dc.contributor.localIdA00983-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid25668207-
dc.contributor.alternativeNameKim, Ji Young-
dc.contributor.alternativeNameKim, Jee Hwan-
dc.contributor.alternativeNameOh, Yoon Soo-
dc.contributor.alternativeNameLee, Jae Hoon-
dc.contributor.alternativeNameHan, Dong Hoo-
dc.contributor.affiliatedAuthorKim, Jee Hwan-
dc.contributor.affiliatedAuthorOh, Yoon Soo-
dc.contributor.affiliatedAuthorHan, Dong Hoo-
dc.contributor.affiliatedAuthorLee, Jae Hoon-
dc.contributor.affiliatedAuthorKim, Ji Young-
dc.rights.accessRightsfree-
dc.citation.volume10-
dc.citation.number2-
dc.citation.startPagee0118084-
dc.identifier.bibliographicCitationPLOS ONE, Vol.10(2) : e0118084, 2015-
Appears in Collections:
5. Research Institutes (연구소) > Oral Science Research Center (구강과학연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers

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