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The Role of Orexin in Post- Stroke; Emphasizing on Inflammation, Cognitive decline, Depression following Stroke.

Authors
 Juhyun Song  ;  Eosu Kim  ;  Chul-Hoon Kim  ;  Ho-Taek Song  ;  Jong Eun Lee 
Citation
 MOLECULAR BRAIN, Vol.8 : 16, 2015 
Journal Title
 MOLECULAR BRAIN 
Issue Date
2015
MeSH
Animals ; Cognition Disorders/etiology* ; Cognition Disorders/metabolism ; Depression/etiology* ; Depression/metabolism ; Humans ; Inflammation/etiology* ; Inflammation/metabolism ; Models, Biological ; Orexins/metabolism* ; Stroke/complications* ; Stroke/metabolism
Keywords
Post-stroke ; Orexin ; Inflammation ; Cognitive dysfunction ; Depression
Abstract
Ischemic stroke results in diverse pathophysiologies, including cerebral inflammation, neuronal loss, cognitive dysfunction, and depression. Studies aimed at identifying therapeutic solutions to alleviate these outcomes are important due to the increase in the number of stroke patients annually. Recently, many studies have reported that orexin, commonly known as a neuropeptide regulator of sleep/wakefulness and appetite, is associated with neuronal cell apoptosis, memory function, and depressive symptoms. Here, we briefly summarize recent studies regarding the role and future perspectives of orexin in post-ischemic stroke. This review advances our understanding of the role of orexin in post-stroke pathologies, focusing on its possible function as a therapeutic regulator in the post-ischemic brain. Ultimately, we suggest the clinical potential of orexin to regulate post-stroke pathologies.
DOI
10.1186/s13041-015-0106-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eosu(김어수) ORCID logo https://orcid.org/0000-0001-9472-9465
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Song, Ju Hyun(송주현)
Song, Ho Taek(송호택) ORCID logo https://orcid.org/0000-0002-6655-2575
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139599
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