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The sul1 gene in Stenotrophomonas maltophilia with high-level resistance to trimethoprim/sulfamethoxazole

DC Field Value Language
dc.contributor.author이경원-
dc.contributor.author정윤섭-
dc.date.accessioned2016-02-04T11:02:47Z-
dc.date.available2016-02-04T11:02:47Z-
dc.date.issued2015-
dc.identifier.issn2234-3806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139542-
dc.description.abstractEmerging resistance to trimethoprim/sulfamethoxazole (SXT) poses a serious threat to the treatment of Stenotrophomonas maltophilia infections. We determined the prevalence and molecular characteristics of acquired SXT resistance in recent clinical S. maltophilia isolates obtained from Korea. A total of 252 clinical isolates of S. maltophilia were collected from 10 university hospitals in Korea between 2009 and 2010. Antimicrobial susceptibility was determined by using the CLSI agar dilution method. The sul1, sul2, and sul3 genes, integrons, insertion sequence common region (ISCR) elements, and dfrA genes were detected using PCR. The presence of the sul1 gene and integrons was confirmed through sequence analysis. Among the 32 SXT-resistant isolates, sul1 was detected in 23 isolates (72%), all of which demonstrated high-level resistance (≥64 mg/L) to SXT. The sul1 gene (varying in size and structure) was linked to class 1 integrons in 15 of the 23 isolates (65%) harboring this gene. None of the SXT-susceptible isolates or the SXT-resistant isolates with a minimum inhibitory concentration of 4 and 8 mg/L were positive for sul1. Moreover, the sul2, sul3, and dfrA genes or the ISCR elements were not detected. The sul1 gene may play an important role in the high-level SXT resistance observed in S. maltophilia.-
dc.description.statementOfResponsibilityopen-
dc.format.extent246~249-
dc.relation.isPartOfANNALS OF LABORATORY MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnti-Bacterial Agents/pharmacology-
dc.subject.MESHBacterial Proteins/genetics*-
dc.subject.MESHDrug Resistance, Bacterial/genetics-
dc.subject.MESHGram-Negative Bacterial Infections/microbiology-
dc.subject.MESHGram-Negative Bacterial Infections/pathology-
dc.subject.MESHHumans-
dc.subject.MESHIntegrons/genetics*-
dc.subject.MESHMicrobial Sensitivity Tests-
dc.subject.MESHStenotrophomonas maltophilia/drug effects*-
dc.subject.MESHStenotrophomonas maltophilia/genetics-
dc.subject.MESHStenotrophomonas maltophilia/isolation & purification-
dc.subject.MESHTrimethoprim, Sulfamethoxazole Drug Combination/pharmacology*-
dc.titleThe sul1 gene in Stenotrophomonas maltophilia with high-level resistance to trimethoprim/sulfamethoxazole-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorHae-Sun Chung-
dc.contributor.googleauthorKyeongmi Kim-
dc.contributor.googleauthorSang Sook Hong-
dc.contributor.googleauthorSeong Geun Hong-
dc.contributor.googleauthorKyungwon Lee-
dc.contributor.googleauthorYunsop Chong-
dc.identifier.doi10.3343/alm.2015.35.2.246-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02649-
dc.contributor.localIdA03679-
dc.relation.journalcodeJ00164-
dc.identifier.eissn2234-3814-
dc.identifier.pmid25729729-
dc.subject.keywordClass 1 integron-
dc.subject.keywordStenotrophomonas maltophilia-
dc.subject.keywordTrimethoprim/sulfamethoxazole-
dc.subject.keywordsul-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.alternativeNameChong, Yun Sop-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorChong, Yun Sop-
dc.rights.accessRightsfree-
dc.citation.volume35-
dc.citation.number2-
dc.citation.startPage246-
dc.citation.endPage249-
dc.identifier.bibliographicCitationANNALS OF LABORATORY MEDICINE, Vol.35(2) : 246-249, 2015-
dc.identifier.rimsid56491-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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