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Metaplastic carcinoma show different expression pattern of YAP compared to triple-negative breast cancer

DC FieldValueLanguage
dc.contributor.author구자승-
dc.contributor.author김상겸-
dc.contributor.author정우희-
dc.contributor.author김혜민-
dc.date.accessioned2016-02-04T11:02:16Z-
dc.date.available2016-02-04T11:02:16Z-
dc.date.issued2015-
dc.identifier.issn1010-4283-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139523-
dc.description.abstractThe purpose of this study is to examine the expression of Yes-associated protein (YAP) in metaplastic carcinoma and compare to those of triple-negative breast carcinoma (TNBC) for investigation of its implication. Tissue microarrays containing 34 cases of metaplastic carcinoma and 175 cases of TNBC were constructed and immunohistochemical staining was used to evaluate expression of the following proteins: YAP and phosphorylated YAP (pYAP). According to immunohistochemical staining results of cytokeratin 5/6, EGFR, claudin 3, claudin 4, claudin 7, E-cadherin, STAT-1, androgen receptor, and GGT-1, metaplastic carcinoma and TNBC were sub-classified into six subtypes: basal-like type, molecular apocrine type, claudin-low type, immune-related type, mixed type, and null type. Comparing the expression of YAP and pYAP in metaplastic carcinoma and TNBC, the expression of nuclear YAP (p = 0.025), cytoplasmic pYAP (p = 0.010), and nuclear pYAP (p = 0.014) in tumor cell was higher in metaplastic carcinoma than TNBC. In metaplastic carcinoma, the nuclear YAP expression in tumor cell was associated with loss of E-cadherin (p = 0.020) and claudin type (p = 0.020), and the stromal YAP expression was associated with claudin 7 positivity (p = 0.003). In conclusion, the YAP expression in metaplastic carcinoma is higher than that in TNBC, representing the association of stemness and epithelial-mesenchymal transition features in metaplastic carcinoma.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfTUMOR BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdaptor Proteins, Signal Transducing/biosynthesis-
dc.subject.MESHAdaptor Proteins, Signal Transducing/genetics*-
dc.subject.MESHAdult-
dc.subject.MESHCarcinoma/genetics*-
dc.subject.MESHCarcinoma/pathology-
dc.subject.MESHClaudin-3/biosynthesis-
dc.subject.MESHEpithelial-Mesenchymal Transition/genetics-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation, Neoplastic/genetics-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMetaplasia/genetics*-
dc.subject.MESHMetaplasia/pathology-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Proteins/biosynthesis-
dc.subject.MESHPhosphoproteins/biosynthesis-
dc.subject.MESHPhosphoproteins/genetics*-
dc.subject.MESHPrognosis-
dc.subject.MESHReceptors, Androgen/biosynthesis-
dc.subject.MESHTriple Negative Breast Neoplasms/genetics*-
dc.subject.MESHTriple Negative Breast Neoplasms/pathology-
dc.titleMetaplastic carcinoma show different expression pattern of YAP compared to triple-negative breast cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorHye min Kim-
dc.contributor.googleauthorSang Kyum Kim-
dc.contributor.googleauthorWoo Hee Jung-
dc.contributor.googleauthorJa Seung Koo-
dc.identifier.doi10.1007/s13277-014-2735-x-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00198-
dc.contributor.localIdA00520-
dc.contributor.localIdA03671-
dc.relation.journalcodeJ02763-
dc.identifier.eissn1423-0380-
dc.identifier.pmid25344213-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs13277-014-2735-x-
dc.subject.keywordBreast cancer-
dc.subject.keywordMetaplastic carcinoma-
dc.subject.keywordYAP-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameKim, Sang Kyum-
dc.contributor.alternativeNameJung, Woo Hee-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorKim, Sang Kyum-
dc.contributor.affiliatedAuthorJung, Woo Hee-
dc.contributor.affiliatedAuthor구자승-
dc.rights.accessRightsnot free-
dc.citation.volume36-
dc.citation.number2-
dc.citation.startPage1207-
dc.citation.endPage1212-
dc.identifier.bibliographicCitationTUMOR BIOLOGY, Vol.36(2) : 1207-1212, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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