Cited 6 times in
The association between genetic variants of RUNX2, ADIPOQ and vertebral fracture in Korean postmenopausal women
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2016-02-04T11:01:38Z | - |
dc.date.available | 2016-02-04T11:01:38Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0914-8779 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139500 | - |
dc.description.abstract | Contrary to the traditional belief that obesity acts as a protective factor for bone, recent epidemiologic studies have shown that body fat might be a risk factor for osteoporosis and bone fracture. Accordingly, we evaluated the association between the phenotypes of osteoporosis or vertebral fracture and variants of obesity-related genes, peroxisome proliferator-activated receptor-gamma (PPARG), runt-related transcription factor 2 (RUNX2), leptin receptor (LEPR), and adiponectin (ADIPOQ). In total, 907 postmenopausal healthy women, aged 60-79 years, were included in this study. BMD and biomarkers of bone health and adiposity were measured. We genotyped for four single nucleotide polymorphisms (SNPs) from four genes (PPARG, RUNX2, LEPR, ADIPOQ). A general linear model for continuous dependent variables and a logistic regression model for categorical dependent variables were used to analyze the statistical differences among genotype groups. Compared with the TT subjects at rs7771980 in RUNX2, C-carrier (TC + CC) subjects had a lower vertebral fracture risk after adjusting for age, smoking, alcohol, total calorie intake, total energy expenditure, total calcium intake, total fat intake, weight, body fat. Odds ratio (OR) and 95% interval (CI) for the vertebral fracture risk was 0.55 (95% CI 0.32-0.94). After adjusting for multiple variables, the prevalence of vertebral fracture was highest in GG subjects at rs1501299 in ADIPOQ (p = 0.0473). A high calcium intake (>1000 mg/day) contributed to a high bone mineral density (BMD) in GT + TT subjects at rs1501299 in ADIPOQ (p for interaction = 0.0295). Even if the mechanisms between obesity-related genes and bone health are not fully established, the results of our study revealed the association of certain SNPs from obesity-related genes with BMD or vertebral fracture risk in postmenopausal Korean women. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 173~179 | - |
dc.relation.isPartOf | JOURNAL OF BONE AND MINERAL METABOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adiponectin/genetics* | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics* | - |
dc.subject.MESH | Body Weight/genetics | - |
dc.subject.MESH | Bone Density/genetics | - |
dc.subject.MESH | Core Binding Factor Alpha 1 Subunit/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genetic Predisposition to Disease/genetics* | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Obesity/genetics | - |
dc.subject.MESH | Osteoporosis, Postmenopausal/genetics | - |
dc.subject.MESH | Polymorphism, Single Nucleotide/genetics* | - |
dc.subject.MESH | Postmenopause/genetics* | - |
dc.subject.MESH | Spinal Fractures/genetics* | - |
dc.title | The association between genetic variants of RUNX2, ADIPOQ and vertebral fracture in Korean postmenopausal women | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Kyong-Chol Kim | - |
dc.contributor.googleauthor | Hyejin Chun | - |
dc.contributor.googleauthor | ChaoQiang Lai | - |
dc.contributor.googleauthor | Laurence D. Parnell | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Jongho Lee | - |
dc.contributor.googleauthor | Jose. M. Ordovas | - |
dc.identifier.doi | 10.1007/s00774-014-0570-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J01277 | - |
dc.identifier.eissn | 1435-5604 | - |
dc.identifier.pmid | 24570271 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00774-014-0570-1 | - |
dc.subject.keyword | Polymorphisms | - |
dc.subject.keyword | Runt-related transcription factor 2 (RUNX2) | - |
dc.subject.keyword | Adiponectin (ADIPOQ) | - |
dc.subject.keyword | Osteoporosis | - |
dc.subject.keyword | Vertebral fracture | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 33 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 173 | - |
dc.citation.endPage | 179 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BONE AND MINERAL METABOLISM, Vol.33(2) : 173-179, 2015 | - |
dc.identifier.rimsid | 55434 | - |
dc.type.rims | ART | - |
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