Cited 29 times in
Selective PCAF inhibitor ameliorates cognitive and behavioral deficits by suppressing NF-κB-mediated neuroinflammation induced by Aβ in a model of Alzheimer's disease
DC Field | Value | Language |
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dc.contributor.author | 박수연 | - |
dc.contributor.author | 윤호근 | - |
dc.date.accessioned | 2016-02-04T11:01:18Z | - |
dc.date.available | 2016-02-04T11:01:18Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1107-3756 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139489 | - |
dc.description.abstract | Several recent studies have reported an association between neurodegeneration and histone modifications, such as acetylation, deacetylation and methylation. In addition, questions have been raised regarding a potential functional role for the histone acetylation enzymes in β-amyloid (Aβ)-mediated neurotoxicity, particularly the p300/CBP-associated factor (PCAF) enzyme. We recently reported the potential utility of a PCAF inhibitor in the suppression of Aβ-induced neuronal cell death, although the in vivo effectiveness of the PCAF inhibitor remained unclear. In this study, we modified the PCAF inhibitor by chemical derivatization and selected compound C-30-27 as the most potent PCAF inhibitor. We demonstrated that C-30-27 selectively inhibited acetylation-dependent nuclear factor-κB (NF-κB) at Lys-122 and suppressed the NF-κB-mediated inflammatory response induced by lipopolysaccharide (LPS) or Aβ in both BV2 and Neuro-2A (N2A) cells. Finally, we demonstrated that C-30-27 improved cognitive deficits, as well as the capacity for locomotion and the damaged cholinergic system in the Aβ-treated rats. In conclusion, our results demonstrate that this selective PCAF inhibitor has the potential to reduce the neuroinflammatory response induced by Aβ. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1109~1118 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acetylation/drug effects | - |
dc.subject.MESH | Acetylcholine/metabolism | - |
dc.subject.MESH | Acetylcholinesterase/metabolism | - |
dc.subject.MESH | Alzheimer Disease/metabolism* | - |
dc.subject.MESH | Alzheimer Disease/psychology | - |
dc.subject.MESH | Amyloid beta-Peptides/metabolism* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Behavior, Animal/drug effects* | - |
dc.subject.MESH | Cell Death/drug effects | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Cognition/drug effects* | - |
dc.subject.MESH | Cytokines/biosynthesis | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Enzyme Inhibitors/chemistry | - |
dc.subject.MESH | Enzyme Inhibitors/pharmacology* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Microglia/drug effects | - |
dc.subject.MESH | Microglia/metabolism | - |
dc.subject.MESH | NF-kappa B/metabolism* | - |
dc.subject.MESH | Neurons/drug effects | - |
dc.subject.MESH | Neurons/metabolism | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | p300-CBP Transcription Factors/antagonists & inhibitors* | - |
dc.title | Selective PCAF inhibitor ameliorates cognitive and behavioral deficits by suppressing NF-κB-mediated neuroinflammation induced by Aβ in a model of Alzheimer's disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Biochemistry & Molecular Biology (생화학,분자생물학) | - |
dc.contributor.googleauthor | Soo-Yeon Park | - |
dc.contributor.googleauthor | Mi-Jeong Kim | - |
dc.contributor.googleauthor | Young Jun Kim | - |
dc.contributor.googleauthor | Yoo-Hyun Lee | - |
dc.contributor.googleauthor | Donghyuk Bae | - |
dc.contributor.googleauthor | Sunoh Kim | - |
dc.contributor.googleauthor | Younghwa Na | - |
dc.contributor.googleauthor | Ho-Geun Yoon | - |
dc.identifier.doi | 10.3892/ijmm.2015.2099 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02625 | - |
dc.contributor.localId | A01534 | - |
dc.relation.journalcode | J01132 | - |
dc.identifier.eissn | 1791-244X | - |
dc.identifier.pmid | 25672970 | - |
dc.identifier.url | http://www.spandidos-publications.com/ijmm/35/4/1109 | - |
dc.subject.keyword | Alzheimer's disease | - |
dc.subject.keyword | P300/CBP-associated factor | - |
dc.subject.keyword | inflammation | - |
dc.subject.keyword | nuclear factor-κB | - |
dc.subject.keyword | neurotoxicity | - |
dc.subject.keyword | β-amyloid | - |
dc.subject.keyword | cognitive deficit | - |
dc.contributor.alternativeName | Park, Soo Yeon | - |
dc.contributor.alternativeName | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | Yoon, Ho Geun | - |
dc.contributor.affiliatedAuthor | Park, Soo Yeon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 35 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1109 | - |
dc.citation.endPage | 1118 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Vol.35(4) : 1109-1118, 2015 | - |
dc.identifier.rimsid | 55426 | - |
dc.type.rims | ART | - |
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