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Evolution from WHO to EASL and mRECIST for hepatocellular carcinoma: considerations for tumor response assessment

Authors
 Mi Na Kim  ;  Beom Kyung Kim  ;  Kwang-Hyub Han  ;  Seung Up Kim 
Citation
 EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, Vol.9(3) : 335-348, 2015 
Journal Title
 EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY 
ISSN
 1747-4124 
Issue Date
2015
MeSH
Carcinoma, Hepatocellular/diagnostic imaging* ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/therapy* ; Europe ; Humans ; Liver/pathology* ; Liver Neoplasms/diagnostic imaging* ; Liver Neoplasms/pathology ; Liver Neoplasms/therapy* ; Necrosis/diagnostic imaging ; Radiography ; Response Evaluation Criteria in Solid Tumors* ; Societies, Medical* ; Tumor Burden ; United States ; World Health Organization
Keywords
EASL ; RECIST ; WHO ; hepatocellular carcinoma ; mRECIST ; response assessment
Abstract
Radiological response assessment criteria in hepatocellular carcinoma (HCC) have evolved to accurately evaluate tumor responses. The WHO criteria and the subsequent Response Evaluation Criteria in Solid Tumors (RECIST) evaluate change in tumor size; however, these criteria generally ignore tumor necrosis and therefore may underestimate treatment responses. Thus, a panel of experts of the European Association for the Study of Liver (EASL) amended the response criteria to take into account tumor necrosis. In 2010, the modified RECIST (mRECIST) was developed, which consider both the concept of tumor viability based on arterial enhancement and single linear summation, ultimately simplifying EASL criteria. Currently, the mRECIST represents the gold standard for radiologically evaluating tumor response during HCC treatment. Here, the authors review application and performance of mRECIST as well as other HCC response assessment criteria and discuss unmet and open issues regarding response evaluation for HCC treatments.
Full Text
http://www.tandfonline.com/doi/full/10.1586/17474124.2015.959929
DOI
10.1586/17474124.2015.959929
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Mi Na(김미나)
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139457
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