Cited 22 times in
¹⁸F-FDG PET/CT in hepatocellular carcinoma: detection of bone metastasis and prediction of prognosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강원준 | - |
dc.contributor.author | 김건민 | - |
dc.contributor.author | 김주훈 | - |
dc.contributor.author | 최혜진 | - |
dc.date.accessioned | 2016-02-04T10:58:33Z | - |
dc.date.available | 2016-02-04T10:58:33Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0143-3636 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139391 | - |
dc.description.abstract | OBJECTIVE: The purpose of this study was to assess the diagnostic accuracy and prognostic value of 18F-fluorodeoxyglucose PET/computed tomography (CT) in bone metastases from hepatocellular carcinoma (HCC). PATIENTS AND METHODS: Of 3912 consecutive HCC patients, 67 patients who had undergone both PET/CT and bone scintigraphy (BS) within a 3-month interval were evaluated. RESULTS: Bone metastases were most frequently found in the pelvis (20%), followed by the lumbar spine (14%) and long bones (13%). PET/CT was significantly more sensitive than BS in region-based analyses, with 273 confirmed bone metastases (96.7 vs. 52.7%, respectively; P<0.001), and in patient-based analyses (99 vs. 85%; P=0.042). The median survival period was 5 (range, 0.4-18) months. On univariate analysis, poor prognostic factors included age (<60 years), multiple bone metastases, lymph node metastasis, high serum α-fetoprotein (≥400 IU/ml), Child-Pugh class B, and high maximum standardized uptake value (SUVmax) of bone metastasis (>5.0). Large metabolic volume (≥200 cm3) of bone metastasis was another poor prognostic factor. On Cox regression analysis, high α-fetoprotein was the only poor prognostic factor with statistical significance. CONCLUSION: PET/CT was more sensitive than BS in bone metastasis from HCC by both patient-based and region-based analyses, and offered additional information on survival. PET/CT can be helpful in early diagnosis and opportune treatment of bone metastasis from HCC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 226~233 | - |
dc.relation.isPartOf | NUCLEAR MEDICINE COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Bone Neoplasms/diagnosis* | - |
dc.subject.MESH | Bone Neoplasms/diagnostic imaging | - |
dc.subject.MESH | Bone Neoplasms/secondary* | - |
dc.subject.MESH | Bone and Bones/diagnostic imaging | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorodeoxyglucose F18* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms/pathology* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multimodal Imaging | - |
dc.subject.MESH | Positron-Emission Tomography* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Tomography, X-Ray Computed* | - |
dc.title | ¹⁸F-FDG PET/CT in hepatocellular carcinoma: detection of bone metastasis and prediction of prognosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Nuclear Medicine (핵의학) | - |
dc.contributor.googleauthor | Seo, Hyo Jung | - |
dc.contributor.googleauthor | Kim, Gun Min | - |
dc.contributor.googleauthor | Kim, Joo Hoon | - |
dc.contributor.googleauthor | Kang, Won Jun | - |
dc.contributor.googleauthor | Choi, Hye Jin | - |
dc.identifier.doi | 10.1097/MNM.0000000000000246 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00062 | - |
dc.contributor.localId | A00287 | - |
dc.contributor.localId | A00949 | - |
dc.contributor.localId | A04219 | - |
dc.relation.journalcode | J02384 | - |
dc.identifier.eissn | 1473-5628 | - |
dc.identifier.pmid | 25460306 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006231-201503000-00003&LSLINK=80&D=ovft | - |
dc.subject.keyword | bone metastasis | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | positron emission tomography | - |
dc.subject.keyword | prognosis | - |
dc.contributor.alternativeName | Kang, Won Jun | - |
dc.contributor.alternativeName | Kim, Gun Min | - |
dc.contributor.alternativeName | Kim, Joo Hoon | - |
dc.contributor.alternativeName | Choi, Hye Jin | - |
dc.contributor.affiliatedAuthor | Kang, Won Jun | - |
dc.contributor.affiliatedAuthor | Kim, Gun Min | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hoon | - |
dc.contributor.affiliatedAuthor | Choi, Hye Jin | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 36 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 226 | - |
dc.citation.endPage | 233 | - |
dc.identifier.bibliographicCitation | NUCLEAR MEDICINE COMMUNICATIONS, Vol.36(3) : 226-233, 2015 | - |
dc.identifier.rimsid | 55364 | - |
dc.type.rims | ART | - |
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