Cited 10 times in
Pediatric supratentorial high-grade glioma: multicenter retrospective observational study of the Korean Society for Pediatric Neuro-Oncology
DC Field | Value | Language |
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dc.contributor.author | 김동석 | - |
dc.date.accessioned | 2016-02-04T10:58:06Z | - |
dc.date.available | 2016-02-04T10:58:06Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0167-594X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139375 | - |
dc.description.abstract | We analyzed the prognostic factors of Korean pediatric patients with supratentorial high-grade glioma (HGG). Between 1997 and 2011, 62 patients with 34 glioblastomas and 28 anaplastic gliomas were surgically operated at nine institutions. The male-to-female ratio was 33 to 29 and the median age was 12 years (range 1-18). The prognostic significance of tumor location, extent of removal, pathologic grade, treatment method, and pattern of recurrence was analyzed. The median progression-free survival (PFS) and overall survival (OS) were 9.3 (± 0.8) and 17.8 (± 1.9) months, respectively. Glioblastoma and anaplastic glioma showed OSs of 15.9 (± 1.3) and 19.6 (± 2.4) months, respectively. Based on the univariate analysis, gross total removal (GTR) and initial combined chemoradiotherapy improved PFS (p = 0.012 and p = 0.003) and OS (p = 0.030 and p = 0.013), respectively. Cerebrospinal fluid (CSF) dissemination showed poor OS (p = 0.001). Based on the multivariate analysis, GTR and initial combined chemoradiotherapy resulted in an improved PFS [(hazard ratio 0.360; 95 % CI 0.177-0.733; p = 0.005) and (hazard ratio 0.458; 95 % CI 0.230-0.911; p = 0.026), respectively]. GTR, initial combined chemoradiotherapy, and no CSF seeding resulted in an improved OS [(hazard ratio 0.417; 95 % CI 0.201-0.861; p = 0.018), (hazard ratio 0.406; 95 % CI 0.206-0.800; p = 0.009), and (hazard ratio 0.288; 95 % CI 0.148-0.563; p = 0.000), respectively]. No significant difference in PFS and OS was observed between glioblastoma and anaplastic glioma. CSF dissemination was observed in 22 patients (35.5 %) during total follow-up. Pediatric anaplastic glioma showed poor survival, similarly to glioblastoma. GTR and initial combined chemoradiotherapy were associated with improved survival. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 413~419 | - |
dc.relation.isPartOf | JOURNAL OF NEURO-ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Glioma/diagnosis | - |
dc.subject.MESH | Glioma/pathology | - |
dc.subject.MESH | Glioma/therapy* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Supratentorial Neoplasms/diagnosis | - |
dc.subject.MESH | Supratentorial Neoplasms/pathology | - |
dc.subject.MESH | Supratentorial Neoplasms/therapy* | - |
dc.title | Pediatric supratentorial high-grade glioma: multicenter retrospective observational study of the Korean Society for Pediatric Neuro-Oncology | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurosurgery (신경외과학) | - |
dc.contributor.googleauthor | Tae Young Jung | - |
dc.contributor.googleauthor | Ji Yeoun Lee | - |
dc.contributor.googleauthor | Dong Seok Kim | - |
dc.contributor.googleauthor | Hyeon Jin Park | - |
dc.contributor.googleauthor | Chae Yong Kim | - |
dc.contributor.googleauthor | Young Shin Ra | - |
dc.contributor.googleauthor | Mee Jeong Lee | - |
dc.contributor.googleauthor | Seong Ho Kim | - |
dc.contributor.googleauthor | Hee Jo Baek | - |
dc.contributor.googleauthor | Il Han Kim | - |
dc.contributor.googleauthor | Kyung Duk Park | - |
dc.contributor.googleauthor | Seung Ki Kim | - |
dc.identifier.doi | 10.1007/s11060-014-1653-5 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00402 | - |
dc.relation.journalcode | J01629 | - |
dc.identifier.eissn | 1573-7373 | - |
dc.identifier.pmid | 25366367 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs11060-014-1653-5 | - |
dc.subject.keyword | Anaplastic glioma | - |
dc.subject.keyword | Glioblastoma | - |
dc.subject.keyword | Pediatric | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Supratentorial | - |
dc.contributor.alternativeName | Kim, Dong Seok | - |
dc.contributor.affiliatedAuthor | Kim, Dong Seok | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 121 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 413 | - |
dc.citation.endPage | 419 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEURO-ONCOLOGY, Vol.121(2) : 413-419, 2015 | - |
dc.identifier.rimsid | 39410 | - |
dc.type.rims | ART | - |
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