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Cited 4 times in

Incidence and Survival of Pediatric Soft Tissue Sarcomas: Comparison between Adults and Children

DC FieldValueLanguage
dc.contributor.author김수희-
dc.contributor.author김효송-
dc.contributor.author노재경-
dc.contributor.author라선영-
dc.contributor.author신규호-
dc.contributor.author신상준-
dc.contributor.author안중배-
dc.contributor.author양우익-
dc.contributor.author유철주-
dc.contributor.author임선민-
dc.contributor.author정현철-
dc.contributor.author조용진-
dc.contributor.author한정우-
dc.date.accessioned2016-02-04T10:56:52Z-
dc.date.available2016-02-04T10:56:52Z-
dc.date.issued2015-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139331-
dc.description.abstractPURPOSE: Pediatric-type sarcomas such as rhabdomyosarcoma (RMS), Ewing sarcoma (EWS), primitive neuroectodermal tumor (PNET), and desmoplastic small round-cell tumor (DSRCT) are rare in adults, with limited studies on their prognosis and optimal treatment strategies. We aimed to examine the outcome of children and adult patients with RMS, EWS, PNET, and DSRCT and relevant prognostic factors. MATERIALS AND METHODS: We retrospectively reviewed 220 pediatric-type sarcoma patients at a single institution between 1985 and 2011. Comparisons were made in order to examine differences in demographics, disease characteristics, and survival. Survival analyses were performed using the Kaplan-Meier method with log-rank tests and Cox proportional hazards models. RESULTS: A total of 220 consecutive patients were identified at our institute. Median age was 15.6 years (range, 0 to 81 years) and there were 108 children (49%) and 112 adult patients (51%). According to histological classification, 106 patients (48.2%) had RMS, 60 (27.3%) had EWS, 50 (22.7%) had PNET, and 4 (1.8%) had DSRCT. With a median follow-up period of 6.6 years, the estimated median overall survival (OS) of all patients was 75 months (95% confidence interval [CI], 27.2 to 122.8 months) and median event-free survival (EFS) for all patients was 11 months (95% CI, 8.8 to 13.2 months). No significant difference in OS and EFS was observed between adults and children. In multivariate analysis, distant metastasis (hazard ratio [HR], 1.617; 95% CI, 1.022 to 2.557; p=0.040) and no debulking surgery (HR, 1.443; 95% CI, 1.104 to 1.812; p=0.012) showed independent association with worse OS. CONCLUSION: Metastatic disease and no surgical treatment are poor prognostic factors for OS among pediatric-type sarcomas for both adults and children.-
dc.description.statementOfResponsibilityopen-
dc.format.extent9~17-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleIncidence and Survival of Pediatric Soft Tissue Sarcomas: Comparison between Adults and Children-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSun Min Lim-
dc.contributor.googleauthorCheol Joo Yoo-
dc.contributor.googleauthorJung Woo Han-
dc.contributor.googleauthorYong Jin Cho-
dc.contributor.googleauthorSoo Hee Kim-
dc.contributor.googleauthorJoong Bae Ahn-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorSang Joon Shin-
dc.contributor.googleauthorHyun Cheol Chung-
dc.contributor.googleauthorWoo Ick Yang-
dc.contributor.googleauthorKyoo-Ho Shin-
dc.contributor.googleauthorJae Kyung Rho-
dc.contributor.googleauthorHyo Song Kim-
dc.identifier.doi10.4143/crt.2013.157-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00644-
dc.contributor.localIdA01202-
dc.contributor.localIdA01290-
dc.contributor.localIdA02086-
dc.contributor.localIdA02105-
dc.contributor.localIdA02262-
dc.contributor.localIdA02300-
dc.contributor.localIdA02524-
dc.contributor.localIdA03369-
dc.contributor.localIdA03773-
dc.contributor.localIdA04325-
dc.contributor.localIdA03867-
dc.contributor.localIdA01316-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.identifier.pmid25143049-
dc.subject.keywordDesmoplastic small round-cell tumor-
dc.subject.keywordEwing sarcoma-
dc.subject.keywordPrimitive neuroectodermal tumors-
dc.subject.keywordRhabdomyosarcoma-
dc.contributor.alternativeNameKim, Soo Hee-
dc.contributor.alternativeNameKim, Hyo Song-
dc.contributor.alternativeNameRoh, Jae Kyung-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameShin, Kyoo Ho-
dc.contributor.alternativeNameShin, Sang Joon-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.alternativeNameLyu, Chuhl Joo-
dc.contributor.alternativeNameLim, Sun Min-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameCho, Yong Jin-
dc.contributor.alternativeNameHan, Jung Woo-
dc.contributor.affiliatedAuthorKim, Soo Hee-
dc.contributor.affiliatedAuthorKim, Hyo Song-
dc.contributor.affiliatedAuthorRoh, Jae Kyung-
dc.contributor.affiliatedAuthorShin, Kyoo Ho-
dc.contributor.affiliatedAuthorShin, Sang Joon-
dc.contributor.affiliatedAuthorAhn, Joong Bae-
dc.contributor.affiliatedAuthorYang, Woo Ick-
dc.contributor.affiliatedAuthorLyu, Chuhl Joo-
dc.contributor.affiliatedAuthorLim, Sun Min-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorHan, Jung Woo-
dc.contributor.affiliatedAuthorCho, Yong Jin-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.rights.accessRightsfree-
dc.citation.volume47-
dc.citation.number1-
dc.citation.startPage9-
dc.citation.endPage17-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.47(1) : 9-17, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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