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Early CMV replication and subsequent chronic GVHD have a significant anti-leukemic effect after allogeneic HSCT in acute myeloid leukemia

DC FieldValueLanguage
dc.contributor.author김수정-
dc.contributor.author김유리-
dc.contributor.author김윤덕-
dc.contributor.author김진석-
dc.contributor.author민유홍-
dc.contributor.author장지은-
dc.contributor.author정준원-
dc.date.accessioned2016-02-04T10:56:47Z-
dc.date.available2016-02-04T10:56:47Z-
dc.date.issued2015-
dc.identifier.issn0939-5555-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139328-
dc.description.abstractEarly cytomegalovirus (CMV) replication (eCMV) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been suggested as an independent factor that reduces leukemia relapse risk. We retrospectively analyzed 74 patients with acute myeloid leukemia (AML) who underwent allo-HSCT between August 2006 and September 2012. All recipients were CMV seropositive. In 52 patients, eCMV occurred at a median of 35 days (range, 11-92) after allo-HSCT. Univariate analysis revealed that the factors associated with a reduction in the 5-year cumulative incidence of relapse (CIR) included the first complete remission status at allo-HSCT, non-adverse cytogenetics and molecular abnormalities, pre-transplant serum ferritin level <1,400 mg/dL, chronic graft-versus-host disease (cGVHD), and eCMV. In sub-group analysis, according to the existence of eCMV and cGVHD, those with both eCMV and cGVHD showed the lowest 5-year CIR (P < 0.003). Patients with both eCMV and cGVHD had the best outcome for leukemia-free survival (LFS) (P < 0.001) and OS (P < 0.001). In the CMV-seropositive population, the presence of eCMV in combination with cGVHD had a significant positive effect on LFS and OS after allo-HSCT. When eCMV preceded cGVHD, the relapse rate after allo-HSCT was significantly reduced in patients with AML. Therefore, we suggest that it is critical to have an immunological understanding of the graft-versus-leukemia effect in this setting.-
dc.description.statementOfResponsibilityopen-
dc.format.extent275~282-
dc.relation.isPartOfANNALS OF HEMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcute Disease-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHCytomegalovirus/immunology*-
dc.subject.MESHCytomegalovirus/physiology-
dc.subject.MESHCytomegalovirus Infections/blood-
dc.subject.MESHCytomegalovirus Infections/immunology*-
dc.subject.MESHCytomegalovirus Infections/virology-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGraft vs Host Disease/etiology-
dc.subject.MESHGraft vs Host Disease/immunology*-
dc.subject.MESHGraft vs Host Disease/virology-
dc.subject.MESHHematopoietic Stem Cell Transplantation/adverse effects-
dc.subject.MESHHematopoietic Stem Cell Transplantation/methods*-
dc.subject.MESHHost-Pathogen Interactions/immunology-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHLeukemia, Myeloid/immunology*-
dc.subject.MESHLeukemia, Myeloid/therapy-
dc.subject.MESHLeukemia, Myeloid/virology-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNeoplasm Recurrence, Local/immunology-
dc.subject.MESHNeoplasm Recurrence, Local/virology-
dc.subject.MESHOutcome Assessment (Health Care)/methods-
dc.subject.MESHOutcome Assessment (Health Care)/statistics & numerical data-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTime Factors-
dc.subject.MESHTransplantation, Homologous-
dc.subject.MESHVirus Replication/immunology*-
dc.subject.MESHYoung Adult-
dc.titleEarly CMV replication and subsequent chronic GVHD have a significant anti-leukemic effect after allogeneic HSCT in acute myeloid leukemia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorJi Eun Jang-
dc.contributor.googleauthorSoo Jeong Kim-
dc.contributor.googleauthorJune-Won Cheong-
dc.contributor.googleauthorShin Young Hyun-
dc.contributor.googleauthorYun Deok Kim-
dc.contributor.googleauthorYu Ri Kim-
dc.contributor.googleauthorJin Seok Kim-
dc.contributor.googleauthorYoo Hong Min-
dc.identifier.doi10.1007/s00277-014-2190-1-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00633-
dc.contributor.localIdA00790-
dc.contributor.localIdA01017-
dc.contributor.localIdA01407-
dc.contributor.localIdA03477-
dc.contributor.localIdA03729-
dc.contributor.localIdA00779-
dc.relation.journalcodeJ00161-
dc.identifier.eissn1432-0584-
dc.identifier.pmid25135450-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs00277-014-2190-1-
dc.subject.keywordCytomegalovirus-
dc.subject.keywordChronic GVHD-
dc.subject.keywordHematopoietic stem cell transplantation-
dc.subject.keywordRelapse-
dc.contributor.alternativeNameKim, Soo Jeong-
dc.contributor.alternativeNameKim, Yu Ri-
dc.contributor.alternativeNameKim, Yun Deok-
dc.contributor.alternativeNameKim, Jin Seok-
dc.contributor.alternativeNameMin, Yoo Hong-
dc.contributor.alternativeNameJang, Ji Eun-
dc.contributor.alternativeNameCheong, June Won-
dc.contributor.affiliatedAuthorKim, Soo Jeong-
dc.contributor.affiliatedAuthorKim, Yun Deok-
dc.contributor.affiliatedAuthorKim, Jin Seok-
dc.contributor.affiliatedAuthorMin, Yoo Hong-
dc.contributor.affiliatedAuthorJang, Ji Eun-
dc.contributor.affiliatedAuthorCheong, June-Won-
dc.contributor.affiliatedAuthorKim, Yu Ri-
dc.rights.accessRightsnot free-
dc.citation.volume94-
dc.citation.number2-
dc.citation.startPage275-
dc.citation.endPage282-
dc.identifier.bibliographicCitationANNALS OF HEMATOLOGY, Vol.94(2) : 275-282, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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