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Contralateral kidney volume change as a consequence of ipsilateral parenchymal atrophy promotes overall renal function recovery after partial nephrectomy

DC Field Value Language
dc.contributor.author윤영은-
dc.contributor.author최경화-
dc.contributor.author한웅규-
dc.date.accessioned2016-02-04T10:56:12Z-
dc.date.available2016-02-04T10:56:12Z-
dc.date.issued2015-
dc.identifier.issn0301-1623-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139306-
dc.description.abstractPURPOSE: To evaluate whether ischemic time is related to ipsilateral parenchymal atrophy (IPA) and contralateral compensational hypertrophy (CCH) and how CCH affects late functional outcome after partial nephrectomy. METHODS: Parenchymal kidney volumes and glomerular filtration rate (GFR) were determined preoperatively and at 3, 6, and 12 months postoperatively in 79 patients. Kidney volume was measured by Voxel Plus® 2.5 with a tissue segmentation tool. Correlation analysis and univariate and multivariate regression models were used to evaluate the recovery of IPA, CCH, and GFR. RESULTS: The mean preserved ipsilateral kidney volume was 86.7%. At 12 months, mean IPA and CCH were 3.0 and 4.8%, respectively, and the mean GFR decrease was 8.0%. Ipsilateral volume decrease and contralateral volume increase were significant until 6 months postoperatively (p<0.05, for each). IPA and CCH were greater with a longer ischemic time (>35 min; p=0.029 and 0.003, respectively), and CCH correlated positively with IPA (r2=0.052, p=0.045). On multivariate analysis, IPA correlated with a longer ischemic time and percent of preserved normal parenchymal volume (PPV), and CCH correlated with a longer ischemic time, IPA, PPV, and total parenchymal volume increase. At 12 months postoperatively, CCH correlated with GFR recovery (r2=0.072, p=0.026), and significant predictors of GFR recovery were age, sex, PPV, and CCH. CONCLUSIONS: We present the meaningful possibility that longer ischemic time and less preservation of normal parenchyma cause greater parenchymal atrophy, thereby promoting CCH, which contributes to renal function recovery after partial nephrectomy.-
dc.description.statementOfResponsibilityopen-
dc.format.extent25~32-
dc.relation.isPartOfINTERNATIONAL UROLOGY AND NEPHROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdaptation, Physiological*-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHAtrophy/etiology-
dc.subject.MESHAtrophy/physiopathology-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGlomerular Filtration Rate*-
dc.subject.MESHHumans-
dc.subject.MESHHypertrophy/etiology-
dc.subject.MESHHypertrophy/physiopathology-
dc.subject.MESHKidney/pathology*-
dc.subject.MESHKidney/physiopathology*-
dc.subject.MESHKidney/surgery-
dc.subject.MESHKidney Neoplasms/physiopathology-
dc.subject.MESHKidney Neoplasms/surgery*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNephrectomy/adverse effects-
dc.subject.MESHOrgan Size-
dc.subject.MESHOrgan Sparing Treatments-
dc.subject.MESHPostoperative Period-
dc.subject.MESHPreoperative Period-
dc.subject.MESHSex Factors-
dc.subject.MESHTime Factors-
dc.subject.MESHWarm Ischemia/adverse effects-
dc.titleContralateral kidney volume change as a consequence of ipsilateral parenchymal atrophy promotes overall renal function recovery after partial nephrectomy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Urology (비뇨기과학)-
dc.contributor.googleauthorKyung Hwa Choi-
dc.contributor.googleauthorYoung Eun Yoon-
dc.contributor.googleauthorKwang Hyun Kim-
dc.contributor.googleauthorWoong Kyu Han-
dc.identifier.doi10.1007/s11255-014-0847-2-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02581-
dc.contributor.localIdA04036-
dc.contributor.localIdA04308-
dc.relation.journalcodeJ01177-
dc.identifier.eissn1573-2584-
dc.identifier.pmid25269408-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs11255-014-0847-2-
dc.subject.keywordNephrectomy-
dc.subject.keywordAtrophy-
dc.subject.keywordHypertrophy-
dc.subject.keywordGlomerular filtration rate-
dc.subject.keywordComputed tomography-
dc.subject.keywordVolumetric-
dc.contributor.alternativeNameYoon, Young Eun-
dc.contributor.alternativeNameChoi, Kyung Hwa-
dc.contributor.alternativeNameHan, Woong Kyu-
dc.contributor.affiliatedAuthorYoon, Young Eun-
dc.contributor.affiliatedAuthorChoi, Kyung Hwa-
dc.contributor.affiliatedAuthorHan, Woong Kyu-
dc.rights.accessRightsnot free-
dc.citation.volume47-
dc.citation.number1-
dc.citation.startPage25-
dc.citation.endPage32-
dc.identifier.bibliographicCitationINTERNATIONAL UROLOGY AND NEPHROLOGY, Vol.47(1) : 25-32, 2015-
dc.identifier.rimsid45557-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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