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An update on the diagnosis, treatment, and prognosis of intestinal Behçet's disease

Authors
 Cheon, Jae Hee  ;  Kim, Won Ho 
Citation
 CURRENT OPINION IN RHEUMATOLOGY, Vol.27(1) : 24-31, 2015 
Journal Title
CURRENT OPINION IN RHEUMATOLOGY
ISSN
 1040-8711 
Issue Date
2015
MeSH
Anti-Inflammatory Agents/therapeutic use* ; Behcet Syndrome*/diagnosis ; Behcet Syndrome*/drug therapy ; Behcet Syndrome*/epidemiology ; Diagnostic Imaging/methods* ; Disease Management* ; Global Health ; Humans ; Intestinal Diseases*/diagnosis ; Intestinal Diseases*/drug therapy ; Intestinal Diseases*/epidemiology ; Morbidity/trends ; Survival Rate/trends
Keywords
antitumor necrosis factor-α agent ; diagnostic criteria ; disease activity index ; immunomodulatory ; intestinal Behçet's disease
Abstract
PURPOSE OF REVIEW: This review discusses recent scientific developments in the diagnosis, treatment, and prognosis of intestinal Behçet's disease.

RECENT FINDINGS: Gastrointestinal involvement is a major cause of morbidity and mortality in Behçet's disease. Patient clinical data are scarce because of the rarity of the disease; however, novel diagnostic criteria and disease activity indices have been developed recently to aid treatment of Behçet's disease patients. Current therapies include 5-aminosalicylic acids, corticosteroids, immunomodulators, or antitumor necrosis factor alpha agents. Antitumor necrosis factor alpha agents can achieve clinical responses and remission in patients that were previously nonresponsive to corticosteroids or immunomodulators. Clinical variables, including young age and higher disease activity at the time of diagnosis, volcano-type ulcers, absence of mucosal healing, higher C-reactive protein levels, prior history of surgery, and lack of initial response to medical therapy, can be regarded as poor prognostic factors.

SUMMARY: Previously, the diagnosis and management of intestinal Behçet's disease depended upon the expertise of individual clinicians; however, more standardized medical assessments and improved treatment regimens for Behçet's disease patients are evolving.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00002281-201501000-00005&LSLINK=80&D=ovft
DOI
10.1097/BOR.0000000000000125
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139294
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