Cited 18 times in
Leukopenia predicts remission in patients with inflammatory bowel disease and Behcet's disease on thiopurine maintenance.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 홍성필 | - |
dc.contributor.author | 김덕환 | - |
dc.contributor.author | 김동현 | - |
dc.contributor.author | 김원호 | - |
dc.contributor.author | 김태일 | - |
dc.contributor.author | 박미성 | - |
dc.contributor.author | 박수정 | - |
dc.contributor.author | 천재희 | - |
dc.date.accessioned | 2016-02-04T10:55:49Z | - |
dc.date.available | 2016-02-04T10:55:49Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139292 | - |
dc.description.abstract | BACKGROUNDS: The thiopurine drugs, azathioprine (AZA), and 6-mercaptopurine (6-MP) are well-established drugs for the treatment of inflammatory bowel disease (IBD). Although leukopenia is a well-recognized side effect of AZA/6-MP treatment, its association with therapeutic effects has yet to be determined. We therefore evaluated the influences of thiopurine-induced leukopenia on the long-term prognosis of IBD. METHODS: We included 196 IBD patients [45 with ulcerative colitis (UC), 68 with Crohn's disease (CD), and 83 with intestinal Behçet's disease (BD)] who were treated with AZA/6-MP and achieved remission between January 2006 and December 2012. We retrospectively analyzed patient characteristics, AZA/6-MP maintenance dose (mg/kg), the lowest white blood cell (WBC) count during AZA/6-MP treatment, duration of remission, and the occurrence of relapse. We compared the clinical variables between leukopenic (n = 120, WBC count <4,000/μL) and nonleukopenic (n = 76, WBC count ≥ 4,000/μL) patients. RESULTS: The two groups were well matched for baseline clinical characteristics. The cumulative relapse-free survival rate was higher in the leukopenic group than the nonleukopenic group by Kaplan-Meier survival analysis (log-rank test, P < 0.001). On multivariate analysis, age, duration of AZA/6-MP treatment, presence of macrocytosis, and the presence of leukopenia were negatively associated with relapse (odds ratios 0.975, 0.988, 0.563, and 0.390, respectively). On subgroup analysis, the cumulative relapse-free survival rate was significantly higher in the leukopenic group than in the nonleukopenic group for all types of IBDs, including UC, CD, and intestinal BD (log-rank test, P = 0.032, 0.047, and 0.002, respectively). CONCLUSION: Leukopenia during thiopurine maintenance therapy was associated with prolonged remission in patients with IBD and Behcet's disease. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 195~204 | - |
dc.relation.isPartOf | DIGESTIVE DISEASES AND SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Azathioprine/adverse effects | - |
dc.subject.MESH | Azathioprine/therapeutic use* | - |
dc.subject.MESH | Behcet Syndrome/drug therapy* | - |
dc.subject.MESH | Behcet Syndrome/epidemiology* | - |
dc.subject.MESH | Colitis, Ulcerative/epidemiology* | - |
dc.subject.MESH | Comorbidity | - |
dc.subject.MESH | Crohn Disease/epidemiology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents/adverse effects | - |
dc.subject.MESH | Immunosuppressive Agents/therapeutic use* | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Leukopenia/chemically induced | - |
dc.subject.MESH | Leukopenia/epidemiology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mercaptopurine/adverse effects | - |
dc.subject.MESH | Mercaptopurine/therapeutic use* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Remission Induction | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Young Adult | - |
dc.title | Leukopenia predicts remission in patients with inflammatory bowel disease and Behcet's disease on thiopurine maintenance. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Mi Sung Park | - |
dc.contributor.googleauthor | Dong Hyun Kim | - |
dc.contributor.googleauthor | Duk Hwan Kim | - |
dc.contributor.googleauthor | Soo Jung Park | - |
dc.contributor.googleauthor | Sung Pil Hong | - |
dc.contributor.googleauthor | Tae Il Kim | - |
dc.contributor.googleauthor | Won Ho Kim | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.identifier.doi | 10.1007/s10620-014-3355-4 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A04404 | - |
dc.contributor.localId | A00377 | - |
dc.contributor.localId | A00774 | - |
dc.contributor.localId | A01079 | - |
dc.contributor.localId | A01462 | - |
dc.contributor.localId | A01539 | - |
dc.contributor.localId | A04030 | - |
dc.contributor.localId | A00413 | - |
dc.relation.journalcode | J00737 | - |
dc.identifier.eissn | 1573-2568 | - |
dc.identifier.pmid | 25239495 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs10620-014-3355-4 | - |
dc.subject.keyword | Thiopurine | - |
dc.subject.keyword | Leukopenia | - |
dc.subject.keyword | Inflammatory bowel disease | - |
dc.subject.keyword | Remission | - |
dc.subject.keyword | Relapse | - |
dc.contributor.alternativeName | Hong, Sung Pil | - |
dc.contributor.alternativeName | Kim, Duk Hwan | - |
dc.contributor.alternativeName | Kim, Dong Hyun | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.alternativeName | Kim, Tae Il | - |
dc.contributor.alternativeName | Park, Mi Sung | - |
dc.contributor.alternativeName | Park, Soo Jung | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | Hong, Sung Pil | - |
dc.contributor.affiliatedAuthor | Kim, Duk Hwan | - |
dc.contributor.affiliatedAuthor | Kim, Won Ho | - |
dc.contributor.affiliatedAuthor | Kim, Tae Il | - |
dc.contributor.affiliatedAuthor | Park, Mi Sung | - |
dc.contributor.affiliatedAuthor | Park, Soo Jung | - |
dc.contributor.affiliatedAuthor | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | Kim, Dong Hyun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 60 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 195 | - |
dc.citation.endPage | 204 | - |
dc.identifier.bibliographicCitation | DIGESTIVE DISEASES AND SCIENCES, Vol.60(1) : 195-204, 2015 | - |
dc.identifier.rimsid | 45548 | - |
dc.type.rims | ART | - |
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