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Clinical implications of microsatellite instability in T1 colorectal cancer

DC FieldValueLanguage
dc.contributor.author강정현-
dc.contributor.author김남규-
dc.contributor.author김임경-
dc.contributor.author손승국-
dc.contributor.author이강영-
dc.date.accessioned2016-02-04T10:55:29Z-
dc.date.available2016-02-04T10:55:29Z-
dc.date.issued2015-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139280-
dc.description.abstractPURPOSE: The estimation of regional lymph node metastasis (LNM) risk in T1 colorectal cancer is based on histologic examination and imaging of the primary tumor. High-frequency microsatellite instability (MSI-H) is likely to decrease the possibility of metastasis to either regional lymph nodes or distant organs in colorectal cancers. This study evaluated the clinical implications of MSI in T1 colorectal cancer with emphasis on the usefulness of MSI as a predictive factor for regional LNM. MATERIALS AND METHODS: A total of 133 patients who underwent radical resection for T1 colorectal cancer were included. Genomic DNA was extracted from normal and tumor tissues and amplified by polymerase chain reaction (PCR). Five microsatellite markers, BAT-25, BAT-26, D2S123, D5S346, and D17S250, were used. MSI and clinicopathological parameters were evaluated as potential predictors of LNM using univariate and multivariate analyses. RESULTS: Among 133 T1 colorectal cancer patients, MSI-H, low-frequency microsatellite instability (MSI-L), and microsatellite stable (MSS) colorectal cancers accounted for 7.5%, 6%, and 86.5%, respectively. MSI-H tumors showed a female predominance, a proximal location and more retrieved lymph nodes. Twenty-two patients (16.5%) had regional LNM. Lymphovascular invasion and depth of invasion were significantly associated with LNM. There was no LNM in 10 MSI-H patients; however, MSI status was not significantly correlated with LNM. Disease-free survival did not differ between patients with MSI-H and those with MSI-L/MSS. CONCLUSION: MSI status could serve as a negative predictive factor in estimating LNM in T1 colorectal cancer, given that LNM was not detected in MSI-H patients. However, validation of our result in a different cohort is necessary.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHColorectal Neoplasms/genetics*-
dc.subject.MESHColorectal Neoplasms/pathology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLymph Nodes/pathology-
dc.subject.MESHLymphatic Metastasis/pathology-
dc.subject.MESHMale-
dc.subject.MESHMicrosatellite Instability*-
dc.subject.MESHMicrosatellite Repeats/genetics-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHRisk Factors-
dc.subject.MESHSurvival Analysis-
dc.titleClinical implications of microsatellite instability in T1 colorectal cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorJeonghyun Kang-
dc.contributor.googleauthorHak Woo Lee-
dc.contributor.googleauthorIm-kyung Kim-
dc.contributor.googleauthorNam Kyu Kim-
dc.contributor.googleauthorSeung-Kook Sohn-
dc.contributor.googleauthorKang Young Lee-
dc.identifier.doi10.3349/ymj.2015.56.1.175-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00080-
dc.contributor.localIdA00353-
dc.contributor.localIdA00851-
dc.contributor.localIdA01978-
dc.contributor.localIdA02640-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid25510762-
dc.subject.keywordMicrosatellite instability-
dc.subject.keywordT1-
dc.subject.keywordearly colorectal cancer-
dc.subject.keywordlymph node metastasis-
dc.subject.keywordprognosis-
dc.contributor.alternativeNameKang, Jeong Hyun-
dc.contributor.alternativeNameKim, Nam Kyu-
dc.contributor.alternativeNameKim, Im Kyung-
dc.contributor.alternativeNameSohn, Seung Kook-
dc.contributor.alternativeNameLee, Kang Young-
dc.contributor.affiliatedAuthorKang, Jeong Hyun-
dc.contributor.affiliatedAuthorKim, Nam Kyu-
dc.contributor.affiliatedAuthorKim, Im Kyung-
dc.contributor.affiliatedAuthorSohn, Seung Kook-
dc.contributor.affiliatedAuthorLee, Kang Young-
dc.rights.accessRightsfree-
dc.citation.volume56-
dc.citation.number1-
dc.citation.startPage175-
dc.citation.endPage181-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.56(1) : 175-181, 2015-
dc.identifier.rimsid45540-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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