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Prognostic impact of time to undetectable prostate-specific antigen in patients with positive surgical margins following radical prostatectomy

DC FieldValueLanguage
dc.contributor.author나군호-
dc.contributor.author정병하-
dc.contributor.author지선하-
dc.contributor.author최영득-
dc.contributor.author크리스토스콤니노스-
dc.contributor.author툴리아오패트릭-
dc.contributor.author홍성준-
dc.contributor.author구교철-
dc.date.accessioned2016-02-04T10:55:15Z-
dc.date.available2016-02-04T10:55:15Z-
dc.date.issued2015-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139271-
dc.description.abstractBACKGROUND: The purpose of this article was to determine the impact of time to undetectable prostate-specific antigen (PSA) for predicting biochemical recurrence (BCR) in patients with a positive surgical margin (PSM) following radical prostatectomy (RP). A PSM is an independent predictor of BCR; however, not all patients develop BCR later on. METHODS: A retrospective analysis was conducted on 1,117 consecutive prostate cancer patients who underwent RP without neoadjuvant or adjuvant therapy from July 2005 to December 2009. Of these, 516 (46.2 %) patients without PSMs, and 214 (19.2 %) patients with PSMs who later achieved undetectable PSA, defined as <0.01 ng/ml, were identified. Patients with PSMs were stratified according to time to undetectable PSA dichotomized at 6 weeks and compared with patients without PSMs. Patients with PSMs who did not achieve undetectable PSA were excluded. BCR was defined as two consecutive increases of post-undetectable PSA ≥0.2 ng/ml. RESULTS: During the median follow-up of 58.2 months, patients with PSMs who achieved undetectable PSA in <6 weeks had comparable 5-year BCR-free survival rates to those without PSMs; however, patients with PSMs who achieved undetectable PSA in ≥6 weeks showed significantly lower rates compared with both patients without PSMs (59.2 vs 74.3 %; p < 0.001) and patients with PSMs who achieved undetectable PSA in <6 weeks (59.2 vs 78.8 %; p = 0.004). Among patients with PSMs, multivariate analysis revealed time to undetectable PSA at ≥6 weeks and seminal vesicle invasion to be independent predictors of BCR. No perioperative factors were associated with undetectable PSA at ≥6 weeks. CONCLUSIONS: Patients with PSMs who achieve undetectable PSA in <6 weeks show comparable risks of BCR to patients with negative surgical margins.-
dc.description.statementOfResponsibilityopen-
dc.format.extent693~700-
dc.relation.isPartOfANNALS OF SURGICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHHumans-
dc.subject.MESHKallikreins/blood*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHProstate-Specific Antigen/blood*-
dc.subject.MESHProstatectomy-
dc.subject.MESHProstatic Neoplasms/blood*-
dc.subject.MESHProstatic Neoplasms/pathology-
dc.subject.MESHProstatic Neoplasms/surgery*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTime Factors-
dc.titlePrognostic impact of time to undetectable prostate-specific antigen in patients with positive surgical margins following radical prostatectomy-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorKyo Chul Koo-
dc.contributor.googleauthorPatrick Tuliao-
dc.contributor.googleauthorChristos Komninos-
dc.contributor.googleauthorYoung Deuk Choi-
dc.contributor.googleauthorByung Ha Chung-
dc.contributor.googleauthorSung Joon Hong-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorKoon Ho Rha-
dc.identifier.doi10.1245/s10434-014-4057-z-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01227-
dc.contributor.localIdA03607-
dc.contributor.localIdA03965-
dc.contributor.localIdA04111-
dc.contributor.localIdA04235-
dc.contributor.localIdA04240-
dc.contributor.localIdA04402-
dc.contributor.localIdA00188-
dc.relation.journalcodeJ00179-
dc.identifier.eissn1534-4681-
dc.identifier.pmid25190131-
dc.identifier.urlhttp://link.springer.com/article/10.1245%2Fs10434-014-4057-z-
dc.subject.keywordRadical-
dc.subject.keywordProstatectomy Positive-
dc.subject.keywordSurgical Margin Pelvic-
dc.subject.keywordLymph Node Dissection-
dc.subject.keywordSeminal Vesicle Invasion-
dc.subject.keywordRadical Prostatectomy Specimen-
dc.contributor.alternativeNameRha, Koon Ho-
dc.contributor.alternativeNameChung, Byung Ha-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.contributor.alternativeNameKomninos, Christos-
dc.contributor.alternativeNameTuliao, Patrick-
dc.contributor.alternativeNameHong, Sung Joon-
dc.contributor.alternativeNameKoo, Kyo Chul-
dc.contributor.affiliatedAuthorRha, Koon Ho-
dc.contributor.affiliatedAuthorChung, Byung Ha-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.contributor.affiliatedAuthorChoi, Young Deuk-
dc.contributor.affiliatedAuthorKomninos, Christos-
dc.contributor.affiliatedAuthorTuliao, Patrick-
dc.contributor.affiliatedAuthorHong, Sung Joon-
dc.contributor.affiliatedAuthorKoo, Kyo Chul-
dc.rights.accessRightsnot free-
dc.citation.volume22-
dc.citation.number2-
dc.citation.startPage693-
dc.citation.endPage700-
dc.identifier.bibliographicCitationANNALS OF SURGICAL ONCOLOGY, Vol.22(2) : 693-700, 2015-
dc.identifier.rimsid45534-
dc.type.rimsART-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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