Cited 14 times in
Prognostic impact of time to undetectable prostate-specific antigen in patients with positive surgical margins following radical prostatectomy
DC Field | Value | Language |
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dc.contributor.author | 나군호 | - |
dc.contributor.author | 정병하 | - |
dc.contributor.author | 지선하 | - |
dc.contributor.author | 최영득 | - |
dc.contributor.author | 크리스토스콤니노스 | - |
dc.contributor.author | 툴리아오패트릭 | - |
dc.contributor.author | 홍성준 | - |
dc.contributor.author | 구교철 | - |
dc.date.accessioned | 2016-02-04T10:55:15Z | - |
dc.date.available | 2016-02-04T10:55:15Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139271 | - |
dc.description.abstract | BACKGROUND: The purpose of this article was to determine the impact of time to undetectable prostate-specific antigen (PSA) for predicting biochemical recurrence (BCR) in patients with a positive surgical margin (PSM) following radical prostatectomy (RP). A PSM is an independent predictor of BCR; however, not all patients develop BCR later on. METHODS: A retrospective analysis was conducted on 1,117 consecutive prostate cancer patients who underwent RP without neoadjuvant or adjuvant therapy from July 2005 to December 2009. Of these, 516 (46.2 %) patients without PSMs, and 214 (19.2 %) patients with PSMs who later achieved undetectable PSA, defined as <0.01 ng/ml, were identified. Patients with PSMs were stratified according to time to undetectable PSA dichotomized at 6 weeks and compared with patients without PSMs. Patients with PSMs who did not achieve undetectable PSA were excluded. BCR was defined as two consecutive increases of post-undetectable PSA ≥0.2 ng/ml. RESULTS: During the median follow-up of 58.2 months, patients with PSMs who achieved undetectable PSA in <6 weeks had comparable 5-year BCR-free survival rates to those without PSMs; however, patients with PSMs who achieved undetectable PSA in ≥6 weeks showed significantly lower rates compared with both patients without PSMs (59.2 vs 74.3 %; p < 0.001) and patients with PSMs who achieved undetectable PSA in <6 weeks (59.2 vs 78.8 %; p = 0.004). Among patients with PSMs, multivariate analysis revealed time to undetectable PSA at ≥6 weeks and seminal vesicle invasion to be independent predictors of BCR. No perioperative factors were associated with undetectable PSA at ≥6 weeks. CONCLUSIONS: Patients with PSMs who achieve undetectable PSA in <6 weeks show comparable risks of BCR to patients with negative surgical margins. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 693~700 | - |
dc.relation.isPartOf | ANNALS OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kallikreins/blood* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Prostate-Specific Antigen/blood* | - |
dc.subject.MESH | Prostatectomy | - |
dc.subject.MESH | Prostatic Neoplasms/blood* | - |
dc.subject.MESH | Prostatic Neoplasms/pathology | - |
dc.subject.MESH | Prostatic Neoplasms/surgery* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Time Factors | - |
dc.title | Prognostic impact of time to undetectable prostate-specific antigen in patients with positive surgical margins following radical prostatectomy | - |
dc.type | Article | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.contributor.googleauthor | Kyo Chul Koo | - |
dc.contributor.googleauthor | Patrick Tuliao | - |
dc.contributor.googleauthor | Christos Komninos | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.contributor.googleauthor | Byung Ha Chung | - |
dc.contributor.googleauthor | Sung Joon Hong | - |
dc.contributor.googleauthor | Sun Ha Jee | - |
dc.contributor.googleauthor | Koon Ho Rha | - |
dc.identifier.doi | 10.1245/s10434-014-4057-z | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01227 | - |
dc.contributor.localId | A03607 | - |
dc.contributor.localId | A03965 | - |
dc.contributor.localId | A04111 | - |
dc.contributor.localId | A04235 | - |
dc.contributor.localId | A04240 | - |
dc.contributor.localId | A04402 | - |
dc.contributor.localId | A00188 | - |
dc.relation.journalcode | J00179 | - |
dc.identifier.eissn | 1534-4681 | - |
dc.identifier.pmid | 25190131 | - |
dc.identifier.url | http://link.springer.com/article/10.1245%2Fs10434-014-4057-z | - |
dc.subject.keyword | Radical | - |
dc.subject.keyword | Prostatectomy Positive | - |
dc.subject.keyword | Surgical Margin Pelvic | - |
dc.subject.keyword | Lymph Node Dissection | - |
dc.subject.keyword | Seminal Vesicle Invasion | - |
dc.subject.keyword | Radical Prostatectomy Specimen | - |
dc.contributor.alternativeName | Rha, Koon Ho | - |
dc.contributor.alternativeName | Chung, Byung Ha | - |
dc.contributor.alternativeName | Jee, Sun Ha | - |
dc.contributor.alternativeName | Choi, Young Deuk | - |
dc.contributor.alternativeName | Komninos, Christos | - |
dc.contributor.alternativeName | Tuliao, Patrick | - |
dc.contributor.alternativeName | Hong, Sung Joon | - |
dc.contributor.alternativeName | Koo, Kyo Chul | - |
dc.contributor.affiliatedAuthor | Rha, Koon Ho | - |
dc.contributor.affiliatedAuthor | Chung, Byung Ha | - |
dc.contributor.affiliatedAuthor | Jee, Sun Ha | - |
dc.contributor.affiliatedAuthor | Choi, Young Deuk | - |
dc.contributor.affiliatedAuthor | Komninos, Christos | - |
dc.contributor.affiliatedAuthor | Tuliao, Patrick | - |
dc.contributor.affiliatedAuthor | Hong, Sung Joon | - |
dc.contributor.affiliatedAuthor | Koo, Kyo Chul | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 22 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 693 | - |
dc.citation.endPage | 700 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL ONCOLOGY, Vol.22(2) : 693-700, 2015 | - |
dc.identifier.rimsid | 45534 | - |
dc.type.rims | ART | - |
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