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Photoacoustic imaging of breast microcalcifications: a validation study with 3-dimensional ex vivo data and spectrophotometric measurement.

Authors
 Jeeun Kang  ;  Eun-kyung Kim  ;  Ga Ram Kim  ;  Changhan Yoon  ;  Tai-kyong Song  ;  Jin Ho Chang 
Citation
 JOURNAL OF BIOPHOTONICS, Vol.8(1~2) : 71-80, 2015 
Journal Title
JOURNAL OF BIOPHOTONICS
ISSN
 1864-063X 
Issue Date
2015
MeSH
Breast/metabolism ; Breast/pathology* ; Calcinosis/diagnosis* ; Calcinosis/diagnostic imaging ; Calcium Oxalate/metabolism ; Durapatite/metabolism ; Humans ; Imaging, Three-Dimensional* ; Mammography ; Phantoms, Imaging ; Photoacoustic Techniques* ; Spectrophotometry*
Keywords
Photoacoustic imaging ; breast cancer screening ; calcium oxalate ; hydroxyapatite ; mammography ; microcalcifications ; ultrasonography
Abstract
This paper investigates whether photoacoustic imaging (PAI) can provide the visualization of microcalcifications in breast tissue. For this, the geometrical correlation between the 3-D PA images of breast microcalcifications within ex vivo specimens and the corresponding mammograms was ascertained. Also, the optical absorbance of the calcification compositions (i.e., hydroxyapatite and calcium oxalate) was measured and compared with the PA responses of the microcalcifications. The experimental results demonstrated that the PA images discriminated between the microcalcifications and the surrounding tissue, and their locations in PA images reasonably meshed with those of the microcalcifications appeared in the mammograms. Also, the change in PA signal amplitude along the laser wavelength agreed with the absorbance of hydroxyapatite associated with the relatively high potential of malignant cancers, but not calcium oxalate with only benign cases.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jbio.201300100/abstract
DOI
10.1002/jbio.201300100
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ga Ram(김가람) ORCID logo https://orcid.org/0000-0002-4481-5792
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139257
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