Cited 11 times in
Simultaneous analysis of seven 2-hydroxy fatty acids as tert-butyldimethylsilyl derivatives in plasma by gas chromatography-mass spectrometry
DC Field | Value | Language |
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dc.contributor.author | 이유미 | - |
dc.date.accessioned | 2016-02-04T10:53:40Z | - |
dc.date.available | 2016-02-04T10:53:40Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0269-3879 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139213 | - |
dc.description.abstract | An efficient method for the simultaneous analysis of seven 2-hydroxy fatty acids (2-HFAs) as tert-butyldimethylsilyl (TBDMS) derivative was developed by gas chromatography-mass spectrometry in selected ion monitoring mode. New mass spectral data on 2-hydroxycapric, 2-hydroxypalmitic, 2-hydroxystearic and 2-hydroxybehenic acids as di-TBDMS derivatives for hydroxyl and carboxyl groups were built. Under the optimal conditions, the present method showed a good correlation coefficient (r ≥ 0.999) in the range of 0.01-0.5 µg. The precision showed low relative standard deviation of <10%, and the accuracy (percentage relative error) varied from -5.2 to 0.3 for the seven 2-HFAs studied. Recovery rates of all 2-HFAs were ≥ 93.2% with good precision. When applied to normal human plasma, seven 2-HFAs were positively identified. Therefore, the present efficient method will be useful for simultaneous analysis of 2-HFAs in plasma. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 156~160 | - |
dc.relation.isPartOf | BIOMEDICAL CHROMATOGRAPHY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Fatty Acids/blood* | - |
dc.subject.MESH | Fatty Acids/chemistry | - |
dc.subject.MESH | Fatty Acids/isolation & purification | - |
dc.subject.MESH | Gas Chromatography-Mass Spectrometry/methods* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Linear Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Silanes/chemistry* | - |
dc.title | Simultaneous analysis of seven 2-hydroxy fatty acids as tert-butyldimethylsilyl derivatives in plasma by gas chromatography-mass spectrometry | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Chan Seo | - |
dc.contributor.googleauthor | Jaehwan Yoon | - |
dc.contributor.googleauthor | Yumie Rhee | - |
dc.contributor.googleauthor | Jong-Jin Kim | - |
dc.contributor.googleauthor | Sang-Jip Nam | - |
dc.contributor.googleauthor | Wonjae Lee | - |
dc.contributor.googleauthor | Gwang Lee | - |
dc.contributor.googleauthor | Sung-Tae Yee | - |
dc.contributor.googleauthor | Man-Jeong Paik | - |
dc.identifier.doi | 10.1002/bmc.3251 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03012 | - |
dc.relation.journalcode | J00316 | - |
dc.identifier.eissn | 1099-0801 | - |
dc.identifier.pmid | 24898098 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/bmc.3251/abstract | - |
dc.subject.keyword | 2-hydroxy fatty acid | - |
dc.subject.keyword | gas chromatography-mass spectrometry | - |
dc.subject.keyword | plasma | - |
dc.subject.keyword | tert-butyldimethylsilylation | - |
dc.contributor.alternativeName | Rhee, Yumie | - |
dc.contributor.affiliatedAuthor | Rhee, Yumie | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 29 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 156 | - |
dc.citation.endPage | 160 | - |
dc.identifier.bibliographicCitation | BIOMEDICAL CHROMATOGRAPHY, Vol.29(1) : 156-160, 2015 | - |
dc.identifier.rimsid | 45496 | - |
dc.type.rims | ART | - |
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