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Preventing metachronous gastric lesions after endoscopic submucosal dissection through Helicobacter pylori eradication

DC FieldValueLanguage
dc.contributor.author김은혜-
dc.contributor.author박준철-
dc.contributor.author박찬혁-
dc.contributor.author신성관-
dc.contributor.author이상길-
dc.contributor.author이용찬-
dc.contributor.author이혁-
dc.contributor.author정성모-
dc.contributor.author정현수-
dc.date.accessioned2016-02-04T10:53:30Z-
dc.date.available2016-02-04T10:53:30Z-
dc.date.issued2015-
dc.identifier.issn0815-9319-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139207-
dc.description.abstractBACKGROUND AND AIM: Metachronous recurrence often occurs after endoscopic submucosal dissection for early gastric cancer, and a method for preventing recurrence is unknown. We aimed to identify risk factors for metachronous lesions, and the effects of aspirin use and Helicobacter pylori eradication on preventing recurrence. METHODS: A total of 1041 consecutive patients who underwent endoscopic submucosal dissection for early gastric cancer between January 2007 and December 2011 were retrospectively analyzed. Every patient was examined endoscopically at 2, 6, and 12 months after endoscopic submucosal dissection, and then annually. Patients were classified into the metachronous group or non-metachronous group according to the existence of metachronous lesions and subdivided by Helicobacter pylori status into three groups: not infected, eradicated after infection, and not eradicated. RESULTS: At 39 months' median follow-up, metachronous gastric lesions had developed in 35 patients (3.4%), including 16 with dysplasia and 19 cancers. Metachronous group were significantly older than non-metachronous group (P = 0.02). Although non-metachronous group took aspirin more frequently than metachronous group (15.5% vs 5.7%), the difference was statistically insignificant (P = 0.11). In the not eradicated group, the odds ratio of metachronous lesion was 7.762 compared with the not infected group (95% confidence interval, 1.483-60.854; P = 0.02). In the eradicated group, the odd ratio of metachronous lesion was 8.120 compared with not infected group (95% confidence interval, 1.950-58.985; P = 0.01). CONCLUSION: Helicobacter pylori infection was an independent risk factor for metachronous gastric lesions. However, eradication of Helicobacter pylori alone does not prevent all metachronous lesions in an inflamed stomach.-
dc.description.statementOfResponsibilityopen-
dc.format.extent75~81-
dc.relation.isPartOfJournal of Gastroenterology and Hepatology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePreventing metachronous gastric lesions after endoscopic submucosal dissection through Helicobacter pylori eradication-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSungmo Jung-
dc.contributor.googleauthorChan Hyuk Park-
dc.contributor.googleauthorEun Hye Kim-
dc.contributor.googleauthorSu Ji Shin-
dc.contributor.googleauthorHyunsoo Chung-
dc.contributor.googleauthorHyuk Lee-
dc.contributor.googleauthorJun Chul Park-
dc.contributor.googleauthorSung Kwan Shin-
dc.contributor.googleauthorYong Chan Lee-
dc.contributor.googleauthorSang Kil Lee-
dc.identifier.doi10.1111/jgh.12687-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01676-
dc.contributor.localIdA01711-
dc.contributor.localIdA02112-
dc.contributor.localIdA02812-
dc.contributor.localIdA02988-
dc.contributor.localIdA03285-
dc.contributor.localIdA03622-
dc.contributor.localIdA00827-
dc.relation.journalcodeJ01417-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/jgh.12687/abstract-
dc.contributor.alternativeNameKim, Eun Hye-
dc.contributor.alternativeNamePark, Jun Chul-
dc.contributor.alternativeNamePark, Chan Hyuk-
dc.contributor.alternativeNameShin, Sung Kwan-
dc.contributor.alternativeNameLee, Sang Kil-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameLee, Hyuk-
dc.contributor.alternativeNameJung, Sung Mo-
dc.contributor.alternativeNameChung, Hyun Soo-
dc.contributor.affiliatedAuthorPark, Jun Chul-
dc.contributor.affiliatedAuthorPark, Chan Hyuk-
dc.contributor.affiliatedAuthorShin, Sung Kwan-
dc.contributor.affiliatedAuthorLee, Sang Kil-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorLee, Hyuk-
dc.contributor.affiliatedAuthorJung, Sung Mo-
dc.contributor.affiliatedAuthorKim, Eun Hye-
dc.rights.accessRightsnot free-
dc.citation.volume30-
dc.citation.number1-
dc.citation.startPage75-
dc.citation.endPage81-
dc.identifier.bibliographicCitationJournal of Gastroenterology and Hepatology, Vol.30(1) : 75-81, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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