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Clinical outcomes of endoscopic submucosal dissection for early stage esophagogastric junction cancer: a systematic review and meta-analysis

 Chan Hyuk Park  ;  Eun Hye Kim  ;  Ha Yan Kim  ;  Yun Ho Roh  ;  Yong Chan Lee 
 Digestive and Liver Disease, Vol.47(1) : 37-44, 2015 
Journal Title
 Digestive and Liver Disease 
Issue Date
BACKGROUND: Although endoscopic submucosal dissection has become widely used for the management of selected cases of early gastric cancer, the effects of endoscopic submucosal dissection for esophagogastric junction cancer have not been fully evaluated. METHODS: Medline, Embase, and the Cochrane Library were searched using the primary keywords "endoscopic submucosal dissection," "ESD," "endoscopic resection," "esophagogastric junction," "gastroesophageal junction," and "Barrett." Six short-term clinical outcomes and three long-term oncologic outcomes were extracted. RESULTS: A total of six studies provided data on 359 early stage esophagogastric junction cancers treated with endoscopic submucosal dissection. The pooled estimate of en bloc resection and complete resection was 98.6% (95% confidence interval 95.9-99.6%) and 87.0% (95% confidence interval 79.7-92.0%), respectively. The pooled estimate of stenosis was 6.9% (95% confidence interval 3.2-14.0%). In 269 lesions with curative resection, there was no local recurrence or distant metastasis. In contrast, three local recurrences and two distant metastases occurred in 90 lesions with non-curative resection. CONCLUSIONS: Endoscopic submucosal dissection for early stage esophagogastric junction cancer is a feasible treatment option with high en bloc resection, complete resection rates and an acceptable range of complications. When curative resections are achieved, good oncologic outcomes are likely in the management of early stage esophagogastric junction cancer by endoscopic submucosal dissection.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
김은혜(Kim, Eun Hye) ORCID logo https://orcid.org/0000-0001-6691-6837
김하얀(Kim, Ha Yan)
노윤호(Roh, Yun Ho)
박찬혁(Park, Chan Hyuk)
이용찬(Lee, Yong Chan)
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