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Comparison of surgery plus chemotherapy and palliative chemotherapy alone for advanced gastric cancer with krukenberg tumor

DC FieldValueLanguage
dc.contributor.author조재용-
dc.contributor.author최승호-
dc.date.accessioned2015-12-28T11:17:30Z-
dc.date.available2015-12-28T11:17:30Z-
dc.date.issued2015-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/139124-
dc.description.abstractPURPOSE: This study was conducted to validate the survival benefit of metastasectomy plus chemotherapy over chemotherapy alone for treatment of Krukenberg tumors from gastric cancer and to identify prognostic factors for survival. MATERIALS AND METHODS: Clinical data from 216 patients with Krukenberg tumors from gastric cancer were collected. Patients were divided into two arms according to treatment modality: arm A, metastasectomy plus chemotherapy and arm B, chemotherapy alone. RESULTS: Overall survival (OS) was significantly increased in arm A relative to arm B for patients initially diagnosed with stage IV gastric cancer (18.0 months vs. 8.0 months; p < 0.001) and those with recurrent Krukenberg tumors (19.0 months vs. 9.0 months; p=0.002), respectively. Metastasectomy (hazard ratio [HR], 0.458; 95% confidence interval [CI], 0.287 to 0.732; p=0.001), signet-ring cell pathology (HR, 1.583; 95% CI, 1.057 to 2.371; p=0.026), and peritoneal carcinomatosis (HR, 3.081; 95% CI, 1.610 to 5.895; p=0.001) were significant prognostic factors for survival. CONCLUSION: Metastasectomy plus chemotherapy offers superior OS when compared to palliative chemotherapy alone in gastric cancer with Krukenberg tumor. Prolonged survival applies to all patients, regardless of gastric cancer stage. Metastasectomy, signet-ring cell pathology, and peritoneal carcinomatosis were prognostic factors for survival. Future prospective randomized trials are needed to confirm the optimal treatment strategy for Krukenberg tumors from gastric cancer.-
dc.description.statementOfResponsibilityopen-
dc.format.extent697~705-
dc.relation.isPartOfCANCER RESEARCH AND TREATMENT-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKrukenberg Tumor/drug therapy-
dc.subject.MESHKrukenberg Tumor/secondary*-
dc.subject.MESHKrukenberg Tumor/surgery-
dc.subject.MESHKrukenberg Tumor/therapy*-
dc.subject.MESHMale-
dc.subject.MESHMetastasectomy*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOvarian Neoplasms/drug therapy-
dc.subject.MESHOvarian Neoplasms/secondary*-
dc.subject.MESHOvarian Neoplasms/surgery-
dc.subject.MESHOvarian Neoplasms/therapy*-
dc.subject.MESHPalliative Care*-
dc.subject.MESHPrognosis-
dc.subject.MESHStomach Neoplasms/pathology*-
dc.subject.MESHTreatment Outcome-
dc.titleComparison of surgery plus chemotherapy and palliative chemotherapy alone for advanced gastric cancer with krukenberg tumor-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학)-
dc.contributor.googleauthorJang Ho Cho-
dc.contributor.googleauthorJae Yun Lim-
dc.contributor.googleauthorJae Yong Cho-
dc.contributor.googleauthorSeung Ho Choi-
dc.contributor.googleauthorJong Won Kim-
dc.contributor.googleauthorSung Min Choi-
dc.contributor.googleauthorAh Ran Choi-
dc.identifier.doi10.4143/crt.2013.175-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03899-
dc.contributor.localIdA04102-
dc.relation.journalcodeJ00453-
dc.identifier.eissn2005-9256-
dc.identifier.pmid25648093-
dc.subject.keywordKrukenberg tumor-
dc.subject.keywordMetastasectomy-
dc.subject.keywordPrognosis-
dc.subject.keywordStomach neopla는-
dc.contributor.alternativeNameCho, Jae Yong-
dc.contributor.alternativeNameChoi, Seung Ho-
dc.contributor.affiliatedAuthorCho, Jae Yong-
dc.contributor.affiliatedAuthorChoi, Seung Ho-
dc.citation.volume47-
dc.citation.number4-
dc.citation.startPage697-
dc.citation.endPage705-
dc.identifier.bibliographicCitationCANCER RESEARCH AND TREATMENT, Vol.47(4) : 697-705, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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