0 184

Cited 13 times in

Clinical implications of preoperative and intraoperative liver biopsies for evaluating donor steatosis in living related liver transplantation

 Mi Jung Jun  ;  Ju Hyun Shim  ;  So Yeon Kim  ;  Nieun Seo  ;  Kang Mo Kim  ;  Young Suk Lim  ;  Han Chu Lee  ;  Eunsil Yu  ;  Sung Gyu Lee 
 LIVER TRANSPLANTATION, Vol.20(4) : 437-445, 2014 
Journal Title
Issue Date
Adult ; Alanine Transaminase/blood ; Biopsy ; Blood Pressure ; Body Mass Index ; Cholesterol, LDL/blood ; Fatty Liver/diagnosis* ; Fatty Liver/pathology* ; Female ; Humans ; Liver/pathology ; Liver Failure/surgery ; Liver Transplantation/methods* ; Living Donors* ; Male ; Microcirculation ; Middle Aged ; Predictive Value of Tests ; Sensitivity and Specificity ; Tomography, X-Ray Computed ; Ultrasonography ; Young Adult
The role of liver biopsy in selecting optimal donors is an area of continuing controversy in living donor liver transplantation (LDLT). Our aim was to assess the potential implications of preoperative and intraoperative biopsies for evaluating donor liver fat content. Three thousand eight hundred fifty-nine consecutive subjects underwent predonation needle biopsy of the right lobe, and 1766 of these subjects actually donated their livers for LDLT and underwent intraoperative wedge biopsies of paired right and left lobes. The preoperative workup protocol also included abdominal ultrasonography (USG) and computed tomography (CT). Intersample agreement on steatosis grades (<5%, 5% to <15%, 15% to <30%, and ≥30%) was calculated, and clinicometabolic factors related to sampling variability were evaluated. For detecting ≥30% steatosis in the 3859 potential donors, USG and CT had sensitivities of 84.9% and 57.3%, specificities of 76.3% and 92.7%, positive predictive values of 29.6% and 48.0%, and negative predictive values of 97.7% and 94.8%, respectively. Analyses of the 1766 actual donors showed that with respect to the total steatosis grades of intraoperative right and left biopsies versus preoperative biopsy, 36.7% and 36.0% of the pairs, respectively, differed from the weighted κ values of 0.44 and 0.40. Similar agreement levels existed for macrovesicular and microvesicular steatosis subtypes. The per-subject agreement rate for the total steatosis grade between intraoperative right and left biopsies was 83.6%. According to a multivariate analysis, independent factors affecting the variability of the total steatosis results from preoperative and intraoperative biopsies (major features) were higher systolic blood pressure, body mass index, and alanine aminotransferase values and lower high-density lipoprotein cholesterol values. In conclusion, imaging may be insufficiently sensitive for evaluating donor hepatic steatosis. Preoperative and selective intraoperative liver biopsies are mandatory for assessing donor steatosis in LDLT unless preoperative imaging demonstrates no fat.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Seo, Nieun(서니은) ORCID logo https://orcid.org/0000-0001-8745-6454
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.