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Characterization of CD8(+)CD57(+) T cells in patients with acute myocardial infarction

 Hee Tae Yu  ;  Jong-Chan Youn  ;  Eui-Cheol Shin  ;  Jong-Won Ha  ;  Donghoon Choi  ;  Sungha Park  ;  Chulhee Choi  ;  Jungsul Lee  ;  Ho-Seok Chi  ;  Seunghyun Park  ;  Jino Lee 
 CELLULAR & MOLECULAR IMMUNOLOGY, Vol.12(4) : 466-473, 2015 
Journal Title
Issue Date
Aged ; Aged, 80 and over ; CD57 Antigens/blood ; CD57 Antigens/immunology* ; CD8-Positive T-Lymphocytes/immunology* ; CD8-Positive T-Lymphocytes/metabolism ; Female ; Gene Expression Regulation/immunology* ; Humans ; Lymphocyte Activation* ; Lymphocyte Count ; Male ; Middle Aged ; Myocardial Infarction/blood ; Myocardial Infarction/immunology* ; Myocardial Infarction/mortality*
acute myocardial infarction ; CD8+CD57+ T cells ; immunosenescence
Although T cells are known to be involved in the pathogenesis of coronary artery disease, it is unclear which subpopulation of T cells contributes to pathogenesis in acute myocardial infarction (MI). We studied the immunological characteristics and clinical impact of CD8(+)CD57(+) T cells in acute MI patients. The frequency of CD57(+) cells among CD8(+) T cells was examined in peripheral blood sampled the morning after acute MI events. Interestingly, the frequency of CD57(+) cells in the CD8(+) T-cell population correlated with cardiovascular mortality 6 months after acute MI. The immunological characteristics of CD8(+)CD57(+) T cells were elucidated by surface immunophenotyping, intracellular cytokine staining and flow cytometry. Immunophenotyping revealed that the CD8(+)CD57(+) T cells were activated, senescent T cells with pro-inflammatory and tissue homing properties. Because a high frequency of CD8(+)CD57(+) T cells is associated with short-term cardiovascular mortality in acute MI patients, this specific subset of CD8(+) T cells might contribute to acute coronary events via their pro-inflammatory and high cytotoxic capacities. Identification of a pathogenic CD8(+) T-cell subset expressing CD57 may offer opportunities for the evaluation and management of acute MI.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Yu, Hee Tae(유희태) ORCID logo https://orcid.org/0000-0002-6835-4759
Youn, Jong Chan(윤종찬)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
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