Cited 12 times in
Role of myeloid-derived suppressor cells in mouse pre-sensitized cardiac transplant model.
DC Field | Value | Language |
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dc.contributor.author | 김범석 | - |
dc.date.accessioned | 2015-12-28T11:14:44Z | - |
dc.date.available | 2015-12-28T11:14:44Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1521-6616 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139018 | - |
dc.description.abstract | Harness of sensitized transplantation remains a clinical challenge particularly in parallel with prolonged cold ischemia time (PCI)-mediated injury. Our present study was to test the role of myeloid-derived suppressor cells (MDSCs) in mouse pre-sensitized transplantation. Our findings revealed that CD11b+Gr1(low) MDSC was shown to have strong suppressive activity. MDSCs subsets from the tolerated mice exhibited higher suppressive capacities compared with counterparts from naive (untreated) mice. Depletion of Tregs could not affect splenic CD11b+Gr1(-low) MDSC frequency, but increase peripheral and intragraft CD11b+Gr1(-low) frequency. Intriguingly, boost of Tregs remarkably caused an increase of CD11b+Gr1(-low) frequency in the graft, peripheral blood, and spleen. Furthermore, peripheral CD11b+Gr1(-low) cells were massively accumulated at the early stage when allogeneic immune response was enhanced. Taken together, MDSCs could prevent grafts from PCI-mediated injury independent on Tregs in the pre-sensitized transplant recipients. Utilization of MDSC subset particularly CD11b+Gr1(-low) might provide a novel insight into improving graft outcome under such clinical scenarios. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 8~16 | - |
dc.relation.isPartOf | CLINICAL IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | CD11b Antigen/metabolism | - |
dc.subject.MESH | Cell Count | - |
dc.subject.MESH | Cold Ischemia/adverse effects | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Graft Survival/immunology | - |
dc.subject.MESH | Heart Transplantation* | - |
dc.subject.MESH | Immunophenotyping | - |
dc.subject.MESH | Immunosuppression | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Myeloid Cells/immunology* | - |
dc.subject.MESH | Myeloid Cells/metabolism | - |
dc.subject.MESH | Receptors, Chemokine/metabolism | - |
dc.subject.MESH | Skin Transplantation | - |
dc.subject.MESH | Spleen/cytology | - |
dc.subject.MESH | Spleen/immunology | - |
dc.title | Role of myeloid-derived suppressor cells in mouse pre-sensitized cardiac transplant model. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Weihua Gong | - |
dc.contributor.googleauthor | Fangmin Ge | - |
dc.contributor.googleauthor | Dahai Liu | - |
dc.contributor.googleauthor | Yan Wu | - |
dc.contributor.googleauthor | Fangbing Liu | - |
dc.contributor.googleauthor | Beom Seok Kim | - |
dc.contributor.googleauthor | Tao Huang | - |
dc.contributor.googleauthor | Maria Koulmanda | - |
dc.contributor.googleauthor | Simon C. Robson | - |
dc.contributor.googleauthor | Terry B. Strom | - |
dc.identifier.doi | 10.1016/j.clim.2014.03.013 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00488 | - |
dc.relation.journalcode | J00578 | - |
dc.identifier.eissn | 1521-7035 | - |
dc.identifier.pmid | 24691417 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S1521661614000771 | - |
dc.subject.keyword | Myeloid-derived suppressor cells | - |
dc.subject.keyword | Prolonged cold ischemia time | - |
dc.subject.keyword | Regulatory T cells | - |
dc.subject.keyword | Sensitization | - |
dc.contributor.alternativeName | Kim, Beom Seok | - |
dc.contributor.affiliatedAuthor | Kim, Beom Seok | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 153 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 8 | - |
dc.citation.endPage | 16 | - |
dc.identifier.bibliographicCitation | CLINICAL IMMUNOLOGY, Vol.153(1) : 8-16, 2014 | - |
dc.identifier.rimsid | 52426 | - |
dc.type.rims | ART | - |
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