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Role of myeloid-derived suppressor cells in mouse pre-sensitized cardiac transplant model.

Authors
 Weihua Gong  ;  Fangmin Ge  ;  Dahai Liu  ;  Yan Wu  ;  Fangbing Liu  ;  Beom Seok Kim  ;  Tao Huang  ;  Maria Koulmanda  ;  Simon C. Robson  ;  Terry B. Strom 
Citation
 CLINICAL IMMUNOLOGY, Vol.153(1) : 8-16, 2014 
Journal Title
 CLINICAL IMMUNOLOGY 
ISSN
 1521-6616 
Issue Date
2014
MeSH
Animals ; CD11b Antigen/metabolism ; Cell Count ; Cold Ischemia/adverse effects ; Disease Models, Animal ; Graft Survival/immunology ; Heart Transplantation* ; Immunophenotyping ; Immunosuppression ; Male ; Mice ; Myeloid Cells/immunology* ; Myeloid Cells/metabolism ; Receptors, Chemokine/metabolism ; Skin Transplantation ; Spleen/cytology ; Spleen/immunology
Keywords
Myeloid-derived suppressor cells ; Prolonged cold ischemia time ; Regulatory T cells ; Sensitization
Abstract
Harness of sensitized transplantation remains a clinical challenge particularly in parallel with prolonged cold ischemia time (PCI)-mediated injury. Our present study was to test the role of myeloid-derived suppressor cells (MDSCs) in mouse pre-sensitized transplantation. Our findings revealed that CD11b+Gr1(low) MDSC was shown to have strong suppressive activity. MDSCs subsets from the tolerated mice exhibited higher suppressive capacities compared with counterparts from naive (untreated) mice. Depletion of Tregs could not affect splenic CD11b+Gr1(-low) MDSC frequency, but increase peripheral and intragraft CD11b+Gr1(-low) frequency. Intriguingly, boost of Tregs remarkably caused an increase of CD11b+Gr1(-low) frequency in the graft, peripheral blood, and spleen. Furthermore, peripheral CD11b+Gr1(-low) cells were massively accumulated at the early stage when allogeneic immune response was enhanced. Taken together, MDSCs could prevent grafts from PCI-mediated injury independent on Tregs in the pre-sensitized transplant recipients. Utilization of MDSC subset particularly CD11b+Gr1(-low) might provide a novel insight into improving graft outcome under such clinical scenarios.
Full Text
http://www.sciencedirect.com/science/article/pii/S1521661614000771
DOI
10.1016/j.clim.2014.03.013
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Beom Seok(김범석) ORCID logo https://orcid.org/0000-0002-5732-2583
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139018
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