Cited 5 times in
Recipient hyperbilirubinaemia protects cardiac graft in rat heterotopic heart transplantation.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이성수 | - |
dc.date.accessioned | 2015-12-28T11:13:37Z | - |
dc.date.available | 2015-12-28T11:13:37Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1010-7940 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138975 | - |
dc.description.abstract | OBJECTIVES: Since bilirubin is a known powerful antioxidant, this study examined whether recipient hyperbilirubinaemia protected heart grafts from ischaemia/reperfusion (I/R) injury and chronic rejection associated with rat cardiac transplantation. METHODS: Heterotopic heart transplantation (HTx) was performed using congenitally hyperbilirubinaemic GUNN (j/j) and normobilirubinaemic GUNN (+/+) rats. Syngenic grafts from +/+ rats were transplanted into +/+ or j/j rats with 6 or 18 h cold storage in University of Wisconsin solution to study I/R injury. To evaluate the effect on chronic rejection, Brown Norway rat heart grafts were transplanted into +/+ or j/j rats under short-course tacrolimus immunosuppression. RESULTS: The +/+ grafts in j/j rats demonstrated significantly lower serum creatine phosphokinase and higher left ventricular developed pressures and had smaller infarct areas than +/+ rats at 3 h after reperfusion. Graft survival with 18 h cold storage increased from 0% in +/+ rats to 41.7% in j/j rats. Malondialdehyde (a marker of lipid peroxidation), mRNA of the inflammatory mediators and phosphorylation of ERK1/2 were significantly decreased in the grafts transplanted into j/j rats compared with those transplanted into +/+ rats 1-3 h after reperfusion. The mean allograft survival in j/j recipients was prolonged to a median survival of 150 days from 84 days in +/+ recipients and was associated with less macrophage infiltrates and less intragraft inflammatory cytokine mRNA at d60. In vitro T-cell proliferation was significantly inhibited in the presence of bilirubin. CONCLUSIONS: Recipient hyperbilirubinaemia ameliorated cardiac I/R injury, as well as chronic allograft rejection following HTx via regulation of inflammatory responses or T-cell proliferation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 481~488 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | Cytokines/metabolism | - |
dc.subject.MESH | Graft Survival/physiology* | - |
dc.subject.MESH | Heart Transplantation* | - |
dc.subject.MESH | Hyperbilirubinemia/metabolism* | - |
dc.subject.MESH | Lipid Peroxidation | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Transgenic | - |
dc.subject.MESH | Reperfusion Injury/metabolism* | - |
dc.subject.MESH | Transplantation, Heterotopic* | - |
dc.subject.MESH | Transplantation, Homologous | - |
dc.title | Recipient hyperbilirubinaemia protects cardiac graft in rat heterotopic heart transplantation. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Thoracic & Cardiovascular Surgery (흉부외과학) | - |
dc.contributor.googleauthor | Sungsoo Lee | - |
dc.contributor.googleauthor | Taihei Yamada | - |
dc.contributor.googleauthor | Takaaki Osako | - |
dc.contributor.googleauthor | Donna B. Stolz | - |
dc.contributor.googleauthor | Masanori Abe | - |
dc.contributor.googleauthor | Kenneth R. McCurry | - |
dc.contributor.googleauthor | Noriko Murase | - |
dc.contributor.googleauthor | Joji Kotani | - |
dc.contributor.googleauthor | Atsunori Nakao | - |
dc.identifier.doi | 10.1093/ejcts/ezt402 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02866 | - |
dc.relation.journalcode | J00811 | - |
dc.identifier.eissn | 1873-734X | - |
dc.identifier.pmid | 23946500 | - |
dc.identifier.url | http://ejcts.oxfordjournals.org/content/45/3/481 | - |
dc.subject.keyword | Heart transplantation | - |
dc.subject.keyword | Hyperbilirubinaemia | - |
dc.subject.keyword | Ischaemia reperfusion | - |
dc.contributor.alternativeName | Lee, Sung Soo | - |
dc.contributor.affiliatedAuthor | Lee, Sung Soo | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 45 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 481 | - |
dc.citation.endPage | 488 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol.45(3) : 481-488, 2014 | - |
dc.identifier.rimsid | 51211 | - |
dc.type.rims | ART | - |
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