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Atypical location and clinical behavior of a subset of intracranial germ cell tumors in children younger than 3 years of age.

Authors
 Wan Yee Teo  ;  Jennifer Ross  ;  Robert J. Bollo  ;  Wan Tew Seow  ;  Ah Moy Tan  ;  M.Med.  ;  Seok Gu Kang  ;  Dong Seok Kim  ;  Xiao Nan Li  ;  Ching C. Lau  ;  Carrie A. Mohila  ;  Adekunle M. Adesina  ;  Jack M. Su 
Citation
 Journal of Neurosurgery - Pediatrics, Vol.14(4) : 348-355, 2014 
Journal Title
 Journal of Neurosurgery - Pediatrics 
ISSN
 1933-0707 
Issue Date
2014
MeSH
Brain Neoplasms/diagnosis* ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy* ; Child, Preschool ; Female ; Germinoma/diagnosis* ; Germinoma/pathology ; Germinoma/therapy* ; Humans ; Infant ; Magnetic Resonance Imaging ; Male ; Neoplasms, Germ Cell and Embryonal/diagnosis ; Neoplasms, Germ Cell and Embryonal/therapy ; Photomicrography ; Pineal Gland/pathology ; Survival Analysis ; Tomography, X-Ray Computed
Keywords
intracranial germ cell tumors ; infants ; oncology ; excluding mature teratoma
Abstract
The authors describe a series of 15 intracranial germ cell tumors (IGCTs) excluding mature teratomas; 3 cases in children younger than 3 years of age who were treated at 3 different international institutions over the course of 20 years, and 12 from a PubMed search. These tumors, with possible in utero origins, often occur in atypical locations. The clinical behavior differed significantly from these tumors' counterparts in older children. In this young age group germinoma is highly aggressive, whereas nongerminomatous germ cell tumors may be cured without radiotherapy. Ongoing genomic studies reveal insights to attain an understanding of the biology of these tumors. New treatment strategies are needed to improve outcomes for IGCTs in this age group, particularly for germinomas.
Full Text
http://thejns.org/doi/abs/10.3171/2014.6.PEDS13651
DOI
10.3171/2014.6.PEDS13651
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Gu(강석구) ORCID logo https://orcid.org/0000-0001-5676-2037
Kim, Dong Seok(김동석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138915
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