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Adult height in girls with central precocious puberty treated with gonadotropin-releasing hormone agonist with or without growth hormone

DC Field Value Language
dc.contributor.author권아름-
dc.contributor.author김호성-
dc.contributor.author정모경-
dc.contributor.author채현욱-
dc.contributor.author송경철-
dc.date.accessioned2015-12-28T11:11:58Z-
dc.date.available2015-12-28T11:11:58Z-
dc.date.issued2014-
dc.identifier.issn2287-1012-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138913-
dc.description.abstractPURPOSE: There is controversy surrounding the growth outcomes of treatment with gonadotropin-releasing hormone agonist (GnRHa) in central precocious puberty (CPP). We analyzed height preservation after treatment with GnRHa with and without growth hormone (GH) in girls with CPP. METHODS: We reviewed the medical records of 82 girls with idiopathic CPP who had been treated with GnRHa at Severance Children's Hospital from 2004 to 2014. We assessed the changes in height standard deviation score (SDS) for bone age (BA), and compared adult height (AH) with midparental height (MPH) and predicted adult height (PAH) during treatment in groups received GnRHa alone (n=59) or GnRHa plus GH (n=23). RESULTS: In the GnRHa alone group, the height SDS for BA was increased during treatment. AH (160.4±4.23 cm) was significantly higher than the initial PAH (156.6±3.96 cm) (P<0.001), and it was similar to the MPH (159.9±3.52 cm). In the GnRHa plus GH group, the height SDS for BA was also increased during treatment. AH (159.3±5.33 cm) was also higher than the initial PAH (154.6±2.55 cm) (P<0.001), which was similar to the MPH (158.1±3.31 cm). Height gain was slightly higher than that in the GnRHa alone group, however it statistically showed no significant correlation with GH treatment. CONCLUSION: In CPP girls treated with GnRHa, the height SDS for BA was increased, and the AH was higher than the initial PAH. Combined GH treatment showed a limited increase in height gain.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.relation.isPartOfANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleAdult height in girls with central precocious puberty treated with gonadotropin-releasing hormone agonist with or without growth hormone-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorMo Kyung Jung-
dc.contributor.googleauthorKyung Chul Song-
dc.contributor.googleauthorAh Reum Kwon-
dc.contributor.googleauthorHyun Wook Chae-
dc.contributor.googleauthorDuk Hee Kim-
dc.contributor.googleauthorHo-Seong Kim-
dc.identifier.doi10.6065/apem.2014.19.4.214-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00228-
dc.contributor.localIdA01184-
dc.contributor.localIdA03599-
dc.contributor.localIdA04026-
dc.relation.journalcodeJ00175-
dc.identifier.eissn2287-1292-
dc.identifier.pmid25654068-
dc.subject.keywordCentral precocious puberty-
dc.subject.keywordGonadotropin-releasing hormone-
dc.subject.keywordGrowth hormone-
dc.subject.keywordTreatment outcome-
dc.contributor.alternativeNameKwon, Ah Reum-
dc.contributor.alternativeNameKim, Ho Seong-
dc.contributor.alternativeNameJung, Mo Kyung-
dc.contributor.alternativeNameChae, Hyun Wook-
dc.contributor.affiliatedAuthorKwon, Ah Reum-
dc.contributor.affiliatedAuthorKim, Ho Seong-
dc.contributor.affiliatedAuthorJung, Mo Kyung-
dc.contributor.affiliatedAuthorChae, Hyun Wook-
dc.citation.volume19-
dc.citation.number4-
dc.citation.startPage214-
dc.citation.endPage219-
dc.identifier.bibliographicCitationANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, Vol.19(4) : 214-219, 2014-
dc.identifier.rimsid50754-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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