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Obesity survival paradox in pneumonia: a meta-analysis

DC FieldValueLanguage
dc.contributor.author정금지-
dc.contributor.author지선하-
dc.date.accessioned2015-12-28T11:10:07Z-
dc.date.available2015-12-28T11:10:07Z-
dc.date.issued2014-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138842-
dc.description.abstractBACKGROUND: It is unclear whether an 'obesity survival paradox' exists for pneumonia. Therefore, we conducted a meta-analysis to assess the associations between increased body mass index (BMI), pneumonia risk, and mortality risk. METHODS: Cohort studies were identified from the PubMed and Embase databases. Summary relative risks (RRs) with their corresponding 95% confidence intervals (CIs) were calculated using a random effects model. RESULTS: Thirteen cohort studies on pneumonia risk (n = 1,536,623), and ten cohort studies on mortality (n = 1,375,482) were included. Overweight and obese individuals were significantly associated with an increased risk of pneumonia (RR = 1.33, 95% CI 1.04 to 1.71, P = 0.02, I(2) = 87%). In the dose-response analysis, the estimated summary RR of pneumonia per 5 kg/m(2) increase in BMI was 1.04 (95% CI 1.01 to 1.07, P = 0.01, I(2) = 84%). Inversely, overweight and obese subjects were significantly associated with reduced risk of pneumonia mortality (RR = 0.83, 95% CI 0.77 to 0.91, P < 0.01, I(2) = 34%). The estimated summary RR of mortality per 5 kg/m(2) increase in BMI was 0.95 (95% CI 0.93 to 0.98, P < 0.01, I(2) = 77%). CONCLUSIONS: This meta-analysis suggests that an 'obesity survival paradox' exists for pneumonia. Because this meta-analysis is based on observational studies, more studies are required to confirm the results.-
dc.description.statementOfResponsibilityopen-
dc.format.extent61-
dc.relation.isPartOfBMC MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBody Mass Index*-
dc.subject.MESHCohort Studies-
dc.subject.MESHConfidence Intervals-
dc.subject.MESHDatabases, Factual-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHObesity/complications-
dc.subject.MESHObesity/mortality*-
dc.subject.MESHObservational Studies as Topic-
dc.subject.MESHOverweight/complications-
dc.subject.MESHOverweight/mortality-
dc.subject.MESHPneumonia/complications-
dc.subject.MESHPneumonia/mortality*-
dc.subject.MESHRisk-
dc.subject.MESHRisk Reduction Behavior-
dc.titleObesity survival paradox in pneumonia: a meta-analysis-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health (보건대학원)-
dc.contributor.departmentGraduate School of Public Health (보건대학원)-
dc.contributor.googleauthorWei Nie-
dc.contributor.googleauthorYi Zhang-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorKeum Ji Jung-
dc.contributor.googleauthorBing Li,corresponding-
dc.contributor.googleauthorQingyu Xiucorresponding-
dc.identifier.doi10.1186/1741-7015-12-61-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03580-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ00364-
dc.identifier.eissn1741-7015-
dc.identifier.pmid24722122-
dc.subject.keywordBody mass index-
dc.subject.keywordObesity-
dc.subject.keywordPneumonia-
dc.subject.keywordDose–response relationship-
dc.subject.keywordMeta-analysis-
dc.contributor.alternativeNameJung, Keum Ji-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthorJung, Keum Ji-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.citation.volume12-
dc.citation.startPage61-
dc.identifier.bibliographicCitationBMC MEDICINE, Vol.12 : 61, 2014-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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