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Effects of direct current electric-field using ITO plate on breast cancer cell migration

Authors
 Min Sung Kim  ;  Mi Hee Lee  ;  Byeong Ju Kwon  ;  Hyok Jin Seo  ;  Min Ah Koo  ;  Kyung Eun You  ;  Dohyun Kim  ;  Jong Chul Park 
Citation
 Biomaterials Research, Vol.18 : 10, 2014 
Journal Title
 Biomaterials Research 
ISSN
 1226-4601 
Issue Date
2014
Keywords
Breast cancer cell ; Cell migration ; Electrotaxis ; ITO plate ; MDA-MB-231
Abstract
BACKGROUND: Cell migration is an essential activity of the cells in various biological phenomena. The evidence that electrotaxis plays important roles in many physiological phenomena is accumulating. In electrotaxis, cells move with a directional tendency toward the anode or cathode under direct-current electric fields. Indium tin oxide, commonly referred to as ITO has high luminous transmittance, high infrared reflectance, good electrical conductivity, excellent substrate adherence, hardness and chemical inertness and hence, have been widely and intensively studied for many years. Because of these properties of ITO films, the electrotaxis using ITO plate was evaluated. RESULTS: Under the 0 V/cm condition, MDA-MB-231 migrated randomly in all directions. When 1 V/cm of dc EF was applied, cells moved toward anode. The y forward migration index was -0.046 ± 0.357 under the 0 V/cm and was 0.273 ± 0.231 under direct-current electric field of 1 V/cm. However, the migration speed of breast cancer cell was not affected by direct-current electric field using ITO plate. CONCLUSIONS: In this study, we designed a new electrotaxis system using an ITO coated glass and observed the migration of MDA-MB-231 on direct current electric-field of the ITO glass.
Files in This Item:
T201405698.pdf Download
DOI
10.1186/2055-7124-18-10
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Koo, Min-Ah(구민아) ORCID logo https://orcid.org/0000-0002-8671-1131
Kwon, Byeong-Ju(권병주) ORCID logo https://orcid.org/0000-0001-9916-0546
Kim, Min Sung(김민성)
You, Kyung Eun(류경은)
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Seo, Hyok Jin(서혁진)
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138835
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