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Stimulated Migration and Penetration of Vascular Endothelial Cells Into Poly (L-lactic acid) Scaffolds Under Flow Conditions

 Min Ah Koo  ;  Jae Kyeong Kang  ;  Mi Hee Lee  ;  Hyok Jin Seo  ;  Byeong Ju Kwon  ;  Kyung Eun You  ;  Min Sung Kim  ;  Dohyun Kim  ;  Jong Chul Park 
 Biomaterials Research, Vol.18 : 7-7, 2014 
Journal Title
 Biomaterials Research 
Issue Date
BACKGROUND: The initial procedure of the development of engineered tissues is cell seeding into three-dimensional polymer scaffolds. However, it is hard to make the cells invade into scaffold due to the characteristic of pore and material. Electrospun poly (L-lactic acid) scaffold and flow perfusion system were used to overcome these seeding problems. RESULTS: Before starting the experiment, we set up the parallel plate chamber system to observe endothelial cell migration under flow condition. In individual cell migration model, human umbilical endothelial cells started to migrate in the direction of flow at 8 dyne/cm(2) and we observed the cytoskeleton alignment at 8 dyne/cm(2). This study has demonstrated the possibility to evaluate and analyze cell migration using the parallel plate chamber system and we may predict in vivo cell migration under flow condition based on these results. Also the flow perfusion system was established for the effective cell seeding into at three dimensional scaffolds. Moreover, shear stress induced by flow can enhance cell migration into PLLA scaffold that is in the form of cotton. CONCLUSIONS: Result indicated that cell penetration was achieved under flow condition better and more than under static condition throughout the matrix.
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1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
강재경(Kang, Jae Kyeong)
구민아(Koo, Min-Ah) ORCID logo https://orcid.org/0000-0002-8671-1131
권병주(Kwon, Byeong-Ju) ORCID logo https://orcid.org/0000-0001-9916-0546
김민성(Kim, Min Sung)
류경은(You, Kyung Eun)
박종철(Park, Jong Chul) ORCID logo https://orcid.org/0000-0003-0083-5991
서혁진(Seo, Hyok Jin)
이미희(Lee, Mi Hee) ORCID logo https://orcid.org/0000-0002-9630-7044
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