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The modified Glasgow Prognostic Scores as a predictor in diffuse large B cell lymphoma treated with R-CHOP regimen

DC FieldValueLanguage
dc.contributor.author김수정-
dc.contributor.author김유리-
dc.contributor.author김윤덕-
dc.contributor.author김진석-
dc.contributor.author민유홍-
dc.contributor.author장지은-
dc.contributor.author정준원-
dc.contributor.author현신영-
dc.contributor.author황도유-
dc.date.accessioned2015-12-28T11:09:00Z-
dc.date.available2015-12-28T11:09:00Z-
dc.date.issued2014-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138802-
dc.description.abstractPURPOSE: The modified Glasgow Prognostic Score (mGPS) consisting of serum C-reactive protein and albumin levels, shows significant prognostic value in several types of tumors. We evaluated the prognostic significance of mGPS in 285 patients with diffuse large B cell lymphoma (DLBCL), retrospectively. MATERIALS AND METHODS: According to mGPS classification, 204 patients (71.5%) had an mGPS of 0, 57 (20%) had an mGPS of 1, and 24 (8.5%) had an mGPS of 2. RESULTS: Our study found that high mGPS were associated with poor prognostic factors including older age, extranodal involvement, advanced disease stage, unfavorable International Prognostic Index scores, and the presence of B symptoms. The complete response (CR) rate after 3 cycles of R-CHOP chemotherapy was higher in patients with mGPS of 0 (53.8%) compared to those with mGPS of 1 (33.3%) or 2 (25.0%) (p=0.001). Patients with mGPS of 0 had significantly better overall survival (OS) than those with mGPS=1 and those with mGPS=2 (p=0.036). Multivariate analyses revealed that the GPS score was a prognostic factor for the CR rate of 3 cycle R-CHOP therapy (p=0.044) as well as OS (p=0.037). CONCLUSION: mGPS can be considered a potential prognostic factor that may predict early responses to R-CHOP therapy in DLBCL patients.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1568~1575-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntibodies, Monoclonal, Murine-Derived/therapeutic use-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/therapeutic use*-
dc.subject.MESHC-Reactive Protein/metabolism*-
dc.subject.MESHCyclophosphamide/therapeutic use-
dc.subject.MESHDoxorubicin/therapeutic use-
dc.subject.MESHFemale-
dc.subject.MESHGlasgow Outcome Scale-
dc.subject.MESHHumans-
dc.subject.MESHLymphoma, Large B-Cell, Diffuse/blood-
dc.subject.MESHLymphoma, Large B-Cell, Diffuse/diagnosis*-
dc.subject.MESHLymphoma, Large B-Cell, Diffuse/drug therapy*-
dc.subject.MESHLymphoma, Large B-Cell, Diffuse/mortality-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHPrednisone/therapeutic use-
dc.subject.MESHPrognosis-
dc.subject.MESHRemission Induction-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRituximab-
dc.subject.MESHSerum Albumin/metabolism*-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHVincristine/therapeutic use-
dc.titleThe modified Glasgow Prognostic Scores as a predictor in diffuse large B cell lymphoma treated with R-CHOP regimen-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorYundeok Kim-
dc.contributor.googleauthorSoo Jeong Kim-
dc.contributor.googleauthorDohyu Hwang-
dc.contributor.googleauthorJieun Jang-
dc.contributor.googleauthorShin Young Hyun-
dc.contributor.googleauthorYu Ri Kim-
dc.contributor.googleauthorJin Seok Kim-
dc.contributor.googleauthorYoo Hong Min-
dc.contributor.googleauthorJune Won Cheong-
dc.identifier.doi10.3349/ymj.2014.55.6.1568-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00633-
dc.contributor.localIdA00790-
dc.contributor.localIdA01017-
dc.contributor.localIdA01407-
dc.contributor.localIdA03477-
dc.contributor.localIdA03729-
dc.contributor.localIdA04381-
dc.contributor.localIdA04457-
dc.contributor.localIdA00779-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid25323893-
dc.subject.keywordModified Glasgow Prognostic Score-
dc.subject.keyworddiffuse large B cell lymphoma-
dc.subject.keywordprognostic factor-
dc.contributor.alternativeNameKim, Soo Jeong-
dc.contributor.alternativeNameKim, Yu Ri-
dc.contributor.alternativeNameKim, Yun Deok-
dc.contributor.alternativeNameKim, Jin Seok-
dc.contributor.alternativeNameMin, Yoo Hong-
dc.contributor.alternativeNameJang, Ji Eun-
dc.contributor.alternativeNameCheong, June Won-
dc.contributor.alternativeNameHyun, Shin Yong-
dc.contributor.alternativeNameHwang, Doh Yu-
dc.contributor.affiliatedAuthorKim, Soo Jeong-
dc.contributor.affiliatedAuthorKim, Yun Deok-
dc.contributor.affiliatedAuthorKim, Jin Seok-
dc.contributor.affiliatedAuthorMin, Yoo Hong-
dc.contributor.affiliatedAuthorJang, Ji Eun-
dc.contributor.affiliatedAuthorCheong, June-Won-
dc.contributor.affiliatedAuthorHyun, Shin Yong-
dc.contributor.affiliatedAuthorHwang, Doh Yu-
dc.contributor.affiliatedAuthorKim, Yu Ri-
dc.citation.volume55-
dc.citation.number6-
dc.citation.startPage1568-
dc.citation.endPage1575-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.55(6) : 1568-1575, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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