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Skin Sensitization Evaluation of Dental Calcium Hydroxide Medication with Local Lymph Node Assay Using Bromodeoxyuridine Immunohistochemistry in Balb/c Mice

DC FieldValueLanguage
dc.contributor.author김광만-
dc.contributor.author노지연-
dc.contributor.author정현기-
dc.contributor.author최은옥-
dc.date.accessioned2015-12-28T11:08:05Z-
dc.date.available2015-12-28T11:08:05Z-
dc.date.issued2014-
dc.identifier.issn1975-9657-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138768-
dc.description.abstractMedical devices including dental materials should pass biocompatibility test for the premarket approval. Depending on the categorization of device, required biocompatibility tests are different. During endodontic treatment, calcium hydroxide medication has been used for a long time. However, the clinical cases involving in clinical cases of adverse effects of calcium hydroxide paste were reported in some papers. In addition, due to the alkaline pH, the biocompatibility of calcium hydroxide paste is still questionable for practices. Here, we developed novel root canal treatment calcium hydroxide medication containing silicon-substituted hydroxyl apatite (Si-HA) which has been used as bone graft material. In this study, we conducted hypersensitivity test with LLNA: BrdUELISA method for the evaluation of sensitization potential of allergen. All test methods were according to OECD guideline and ISO 10993 series and results were statistically analysed with SPSS. There were no significant differences among test groups, vehicles and negative control in body weight, ear thickness and ear weight. Only positive control showed statistically significant difference in stimulation index (SI). In conclusion, we assumed that newly developed calcium hydroxide medication has no sensitization material. We also confirmed that LLNA with BrdU using ELISA is appropriate method to identify sensitizing chemicals in dental materials-
dc.description.statementOfResponsibilityopen-
dc.format.extent43~49-
dc.relation.isPartOfJournal of Alternatives to Animal Experiments (동물실험대체법학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSkin Sensitization Evaluation of Dental Calcium Hydroxide Medication with Local Lymph Node Assay Using Bromodeoxyuridine Immunohistochemistry in Balb/c Mice-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Dental Engineering (치과생체재료공학)-
dc.contributor.googleauthorJi Yeon Roh-
dc.contributor.googleauthorEun Ock Choi-
dc.contributor.googleauthorHyun Gi Jeong-
dc.contributor.googleauthorKwang Mahn Kim-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00312-
dc.contributor.localIdA03763-
dc.contributor.localIdA04156-
dc.contributor.localIdA02229-
dc.relation.journalcodeJ01230-
dc.identifier.urlhttp://www.papersearch.net/view/detail.asp?detail_key=1k700236&code=CP00000002-
dc.subject.keywordHypersensitivity test-
dc.subject.keywordLLNA-
dc.subject.keywordCalcium hydroxide paste-
dc.subject.keywordSi-HA-
dc.contributor.alternativeNameKim, Kwang Mahn-
dc.contributor.alternativeNameRoh, Ji Yeon-
dc.contributor.alternativeNameJeong, Hyun Gi-
dc.contributor.alternativeNameChoi, Eun Ock-
dc.contributor.affiliatedAuthorKim, Kwang Mahn-
dc.contributor.affiliatedAuthorJeong, Hyun Gi-
dc.contributor.affiliatedAuthorChoi, Eun Ock-
dc.contributor.affiliatedAuthorRoh, Ji Yeon-
dc.rights.accessRightsfree-
dc.citation.volume8-
dc.citation.number1-
dc.citation.startPage43-
dc.citation.endPage49-
dc.identifier.bibliographicCitationJournal of Alternatives to Animal Experiments (동물실험대체법학회지), Vol.8(1) : 43-49, 2014-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Dental Devices Testing & Evaluation Center (치과의료기기시험평가센터) > 1. Journal Papers

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