Cited 3 times in
Vertebral compression fractures after spine irradiation using conventional fractionation in patients with metastatic colorectal cancer
DC Field | Value | Language |
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dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 장지석 | - |
dc.contributor.author | 최서희 | - |
dc.contributor.author | 이우중 | - |
dc.date.accessioned | 2015-12-28T11:07:35Z | - |
dc.date.available | 2015-12-28T11:07:35Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2234-1900 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138748 | - |
dc.description.abstract | PURPOSE: To evaluate the risk of vertebral compression fracture (VCF) after conventional radiotherapy (RT) for colorectal cancer (CRC) with spine metastasis and to identify risk factors for VCF in metastatic and non-metastatic irradiated spines. MATERIALS AND METHODS: We retrospectively reviewed 68 spinal segments in 16 patients who received conventional RT between 2009 and 2012. Fracture was defined as a newly developed VCF or progression of an existing fracture. The target volume included all metastatic spinal segments and one additional non-metastatic vertebra adjacent to the tumor-involved spines. RESULTS: The median follow-up was 7.8 months. Among all 68 spinal segments, there were six fracture events (8.8%) including three new VCFs and three fracture progressions. Observed VCF rates in vertebral segments with prior irradiation or pre-existing compression fracture were 30.0% and 75.0% respectively, compared with 5.2% and 4.7% for segments without prior irradiation or pre-existing compression fracture, respectively (both p < 0.05). The 1-year fracture-free probability was 87.8% (95% CI, 78.2-97.4). On multivariate analysis, prior irradiation (HR, 7.30; 95% CI, 1.31-40.86) and pre-existing compression fracture (HR, 18.45; 95% CI, 3.42-99.52) were independent risk factors for VCF. CONCLUSION: The incidence of VCF following conventional RT to the spine is not particularly high, regardless of metastatic tumor involvement. Spines that received irradiation and/or have pre-existing compression fracture before RT have an increased risk of VCF and require close observation. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | RADIATION ONCOLOGY JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Vertebral compression fractures after spine irradiation using conventional fractionation in patients with metastatic colorectal cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학) | - |
dc.contributor.googleauthor | Woo Joong Rhee | - |
dc.contributor.googleauthor | Kyung Hwan Kim | - |
dc.contributor.googleauthor | Jee Suk Chang | - |
dc.contributor.googleauthor | Hyun Ju Kim | - |
dc.contributor.googleauthor | Seohee Choi | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.identifier.doi | 10.3857/roj.2014.32.4.221 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00273 | - |
dc.contributor.localId | A04658 | - |
dc.relation.journalcode | J02592 | - |
dc.identifier.eissn | 2234-3164 | - |
dc.identifier.pmid | 25568850 | - |
dc.subject.keyword | Colorectal cancer | - |
dc.subject.keyword | Compression fractures | - |
dc.subject.keyword | Radiotherapy | - |
dc.subject.keyword | Risk factors | - |
dc.subject.keyword | Spinal fractures | - |
dc.subject.keyword | Spinal neoplasm | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.affiliatedAuthor | Koom, Woong Sub | - |
dc.citation.volume | 32 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 221 | - |
dc.citation.endPage | 230 | - |
dc.identifier.bibliographicCitation | RADIATION ONCOLOGY JOURNAL, Vol.32(4) : 221-230, 2014 | - |
dc.identifier.rimsid | 56464 | - |
dc.type.rims | ART | - |
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