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Cited 17 times in

Epidemiology and clinical features of toxigenic culture-confirmed hospital?onset Clostridium difficile infection: A multicentre prospective study in tertiary hospitals of South Korea

DC Field Value Language
dc.contributor.author정수진-
dc.contributor.author최준용-
dc.contributor.author한상훈-
dc.contributor.author김준명-
dc.contributor.author김희정-
dc.contributor.author이경원-
dc.date.accessioned2015-12-28T11:07:18Z-
dc.date.available2015-12-28T11:07:18Z-
dc.date.issued2014-
dc.identifier.issn0022-2615-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138738-
dc.description.abstractHypervirulent Clostridium difficile strains, most notably BI/NAP1/027, have been increasingly emerging in Western countries as local epidemics. We performed a prospective multicentre observational study from December 2011 to May 2012 to identify recent incidences of toxigenic culture-confirmed hospital-onset C. difficile infections (CDI) and their associated clinical characteristics in South Korea. Patients suspected of having been suffering from CDI more than 48 h after admission and aged ≥20 years were prospectively enrolled and provided loose stool specimens. Toxigenic C. difficile culture (anaerobic culture+toxin A/B/binary gene PCR) and PCR ribotyping were performed in one central laboratory. We enrolled 98 toxigenic culture-confirmed CDI-infected patients and 250 toxigenic culture-negative participants from three hospitals. The incidence of toxigenic culture-confirmed hospital-onset CDI cases was 2.7 per 10,000 patient-days. The percentage of severe CDI cases was relatively low at only 3.1%. UK ribotype 018 was the predominant type (48.1%). There were no hypervirulent BI/NAP1/027 isolates identified. The independent risk factors for toxigenic culture-confirmed hospital-onset CDI were invasive procedure (odds ratio (OR) 7.3, P=0.003) and past CDI history within 3 months (OR 28.5, P=0.003). In conclusion, the incidence and severity of CDI in our study were not higher than reported in Western countries.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1542~1551-
dc.relation.isPartOfJOURNAL OF MEDICAL MICROBIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBacterial Toxins/metabolism-
dc.subject.MESHBacteriological Techniques-
dc.subject.MESHClostridium difficile/isolation & purification*-
dc.subject.MESHCross Infection/microbiology*-
dc.subject.MESHEnterocolitis, Pseudomembranous/epidemiology-
dc.subject.MESHEnterocolitis, Pseudomembranous/microbiology*-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHOdds Ratio-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHTertiary Care Centers*-
dc.titleEpidemiology and clinical features of toxigenic culture-confirmed hospital?onset Clostridium difficile infection: A multicentre prospective study in tertiary hospitals of South Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorHeejung Kim-
dc.contributor.googleauthorKyungwon Lee-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorKi Ho Park-
dc.contributor.googleauthorJoon Young Song-
dc.contributor.googleauthorYu Bin Seo-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorJun Hee Woo-
dc.contributor.googleauthorWoo Joo Kim-
dc.contributor.googleauthorJune Myung Kim-
dc.identifier.doi10.1099/jmm.0.070672-0-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA03638-
dc.contributor.localIdA04191-
dc.contributor.localIdA04286-
dc.contributor.localIdA00953-
dc.contributor.localIdA02649-
dc.contributor.localIdA01219-
dc.relation.journalcodeJ01583-
dc.identifier.eissn1473-5644-
dc.identifier.pmid25187603-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameKim, Hee Jung-
dc.contributor.alternativeNameLee, Kyung Won-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorLee, Kyung Won-
dc.contributor.affiliatedAuthorKim, Heejung-
dc.citation.volume63-
dc.citation.number11-
dc.citation.startPage1542-
dc.citation.endPage1551-
dc.identifier.bibliographicCitationJOURNAL OF MEDICAL MICROBIOLOGY, Vol.63(11) : 1542-1551, 2014-
dc.identifier.rimsid38851-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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