Cited 13 times in
Role of 1,25-dihydroxy vitamin D3 and parathyroid hormone in urinary calcium excretion in calcium stone formers.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김원태 | - |
dc.contributor.author | 최영득 | - |
dc.date.accessioned | 2015-12-28T11:07:10Z | - |
dc.date.available | 2015-12-28T11:07:10Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138733 | - |
dc.description.abstract | PURPOSE: To find out the possible role of 1,25(OH)₂ vitamin D₃ [1,25(OH)₂D₃] and parathyroid hormone (PTH) as intrinsic factors in urinary calcium stone formers (SFs), we investigated their relationship with serum and urinary biochemical parameters. MATERIALS AND METHODS: A total of 326 calcium SFs (male: 204, female: 122) were enrolled and underwent outpatient metabolic evaluations including 1,25(OH)₂D₃ and PTH as well as serum and 24-hour urinary biochemical parameters. As control, 163 age- and sex-matched (2:1) individuals (non-SFs) who have never urinary stone episode were included. RESULTS: 1,25(OH)₂D₃ level was positively correlated with urinary calcium excretion (r=0.347, p<0.001). The hypercalciuric group and recurrent SFs had higher serum 1,25(OH)₂D₃ levels than the normocalciuric group (p<0.001) and first SFs (p=0.050). In the adjusted multiple linear regression analysis, serum 1,25(OH)₂D₃ level (β=0.259, p<0.001) and serum PTH level (β=-0.160, p<0.001) were significantly correlated with urinary calcium excretion. The patients in highest tertile of 1,25(OH)₂D₃ had a more than 3.1 fold risk of hypercalciuria than those in the lowest tertile (odds ratio=3.14, 95% confidence interval: 1.431-6.888, p=0.004). No correlation was observed between PTH and 1,25(OH)₂D₃ (R=0.005, p=0.929) in calcium SFs, while a negative correlation was found in controls (R=-0.269, p=0.001). CONCLUSION: 1,25(OH)₂D₃ was closely correlated with urinary calcium excretion, and high 1,25(OH)₂D₃ levels were detected in the hypercalciuric group and in recurrent SFs. However, 1,25(OH)₂D₃ was not correlated with PTH in calcium SFs. These findings suggest that 1,25(OH)₂D₃ might be important intrinsic factor for altered calcium regulation in SFs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1326~1332 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Calcium/metabolism | - |
dc.subject.MESH | Calcium/urine* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Calculi | - |
dc.subject.MESH | Linear Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Parathyroid Hormone/blood | - |
dc.subject.MESH | Parathyroid Hormone/physiology* | - |
dc.subject.MESH | Parathyroid Hormone/urine | - |
dc.subject.MESH | Vitamin D/analogs & derivatives* | - |
dc.subject.MESH | Vitamin D/blood | - |
dc.subject.MESH | Vitamin D/physiology | - |
dc.subject.MESH | Vitamin D/urine | - |
dc.title | Role of 1,25-dihydroxy vitamin D3 and parathyroid hormone in urinary calcium excretion in calcium stone formers. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Urology (비뇨기과학) | - |
dc.contributor.googleauthor | Won Tae Kim | - |
dc.contributor.googleauthor | Yong June Kim | - |
dc.contributor.googleauthor | Seok Joong Yun | - |
dc.contributor.googleauthor | Kyung Sub Shin | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.contributor.googleauthor | Sang Cheol Lee | - |
dc.contributor.googleauthor | Wun Jae Kim | - |
dc.identifier.doi | 10.3349/ymj.2014.55.5.1326 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00773 | - |
dc.contributor.localId | A04111 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 25048492 | - |
dc.subject.keyword | 1,25-dihydroxy-vitamin D₃ | - |
dc.subject.keyword | calcium | - |
dc.subject.keyword | parathyroid hormone | - |
dc.subject.keyword | urolithiasis | - |
dc.contributor.alternativeName | Kim, Won Tae | - |
dc.contributor.alternativeName | Choi, Young Deuk | - |
dc.contributor.affiliatedAuthor | Kim, Won Tae | - |
dc.contributor.affiliatedAuthor | Choi, Young Deuk | - |
dc.citation.volume | 55 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1326 | - |
dc.citation.endPage | 1332 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.55(5) : 1326-1332, 2014 | - |
dc.identifier.rimsid | 38807 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.