Cited 24 times in
Clonality and Resistome analysis of KPC-producing Klebsiella pneumoniae strain isolated in Korea using whole genome sequencing
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 용동은 | - |
dc.contributor.author | 이양순 | - |
dc.date.accessioned | 2015-12-28T11:06:29Z | - |
dc.date.available | 2015-12-28T11:06:29Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138708 | - |
dc.description.abstract | We analyzed the whole genome sequence and resistome of the outbreak Klebsiella pneumoniae strain MP14 and compared it with those of K. pneumoniae carbapenemase- (KPC-) producing isolates that showed high similarity in the NCBI genome database. A KPC-2-producing multidrug-resistant (MDR) K. pneumoniae clinical isolate was obtained from a patient admitted to a Korean hospital in 2011. The strain MP14 was resistant to all tested β-lactams including monobactam, amikacin, levofloxacin, and cotrimoxazole, but susceptible to tigecycline and colistin. Resistome analysis showed the presence of β-lactamase genes including bla KPC-2, bla SHV-11, bla TEM-169, and bla OXA-9. MP14 also possessed aac(6'-)Ib, aadA2, and aph(3'-)Ia as aminoglycoside resistance-encoding genes, mph(A) for macrolides, oqxA and oqxB for quinolone, catA1 for phenicol, sul1 for sulfonamide, and dfrA12 for trimethoprim. Both SNP tree and cgMLST analysis showed the close relatedness with the KPC producers (KPNIH strains) isolated from an outbreak in the USA and colistin-resistant strains isolated in Italy. The plasmid-scaffold genes in plasmids pKpQil, pKpQil-IT, pKPN3, or pKPN-IT were identified in MP14, KPNIH, and Italian strains. The KPC-2-producing MDR K. pneumoniae ST258 stain isolated in Korea was highly clonally related with MDR K. pneumoniae strains from the USA and Italy. Global spread of KPC-producing K. pneumoniae is a worrying phenomenon | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | BIOMED RESEARCH INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Bacterial Proteins/genetics | - |
dc.subject.MESH | Cross Infection/epidemiology | - |
dc.subject.MESH | Cross Infection/genetics | - |
dc.subject.MESH | Disease Outbreaks | - |
dc.subject.MESH | Drug Resistance, Multiple, Bacterial/genetics* | - |
dc.subject.MESH | Genome, Bacterial* | - |
dc.subject.MESH | Genome-Wide Association Study | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Italy | - |
dc.subject.MESH | Klebsiella Infections/epidemiology | - |
dc.subject.MESH | Klebsiella Infections/genetics | - |
dc.subject.MESH | Klebsiella pneumoniae*/genetics | - |
dc.subject.MESH | Klebsiella pneumoniae*/isolation & purification | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Sequence Analysis, DNA* | - |
dc.subject.MESH | United States | - |
dc.subject.MESH | beta-Lactamases/genetics | - |
dc.title | Clonality and Resistome analysis of KPC-producing Klebsiella pneumoniae strain isolated in Korea using whole genome sequencing | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Yangsoon Lee | - |
dc.contributor.googleauthor | Bong-Soo Kim | - |
dc.contributor.googleauthor | Jongsik Chun | - |
dc.contributor.googleauthor | Ji Hyun Yong | - |
dc.contributor.googleauthor | Yeong Seon Lee | - |
dc.contributor.googleauthor | Jung Sik Yoo | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.contributor.googleauthor | Seong Geun Hong | - |
dc.contributor.googleauthor | Roshan D'Souza | - |
dc.contributor.googleauthor | Kenneth S. Thomson | - |
dc.contributor.googleauthor | Kyungwon Lee | - |
dc.contributor.googleauthor | Yunsop Chong | - |
dc.identifier.doi | 10.1155/2014/352862 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02423 | - |
dc.contributor.localId | A02947 | - |
dc.relation.journalcode | J00315 | - |
dc.identifier.eissn | 2314-6141 | - |
dc.identifier.pmid | 25105122 | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.alternativeName | Lee, Yang Soon | - |
dc.contributor.affiliatedAuthor | Yong, Dong Eun | - |
dc.contributor.affiliatedAuthor | Lee, Yang Soon | - |
dc.citation.volume | 2014 | - |
dc.citation.startPage | 352862 | - |
dc.identifier.bibliographicCitation | BIOMED RESEARCH INTERNATIONAL, Vol.2014 : 352862, 2014 | - |
dc.identifier.rimsid | 39375 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.