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Highly fluorescent conjugated polyelectrolyte for protein sensing and cell-compatible chemosensing applications

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dc.contributor.author김한수-
dc.contributor.author김현옥-
dc.contributor.author허준석-
dc.date.accessioned2015-12-28T11:05:26Z-
dc.date.available2015-12-28T11:05:26Z-
dc.date.issued2014-
dc.identifier.issn1944-8244-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138671-
dc.description.abstractUsing a highly fluorescent, water-soluble polymer derived from a triazine-bridged copolymer (DTMSPV), we explored the tunable fluorescence properties of the water-soluble DTMSPV by solvent polarity to function as a fluorescence sensory probe for protein sensing. The green-blue fluorescence from DTMSPV was significantly enhanced in the presence of bovine serum albumin through hydrophobic interactions. Meanwhile, complete quenching of the fluorescence from DTMSPV occurred in the presence of hemoglobin through iron complexation with the polyelectrolyte. In addition, the DTMSPVs were highly fluorescent and permeated into living mesenchymal stem cells (MSCs), enabling effective imaging of the MSCs. This permeation into stem cells is crucial to the detection of Al(3+) in living MSCs. The interaction between the triazine units in DTMSPV with the Al(3+) ions allows for the detection of Al(3+) in living cells. Thus, a strong fluorescence from living MSCs pretreated with DTMSPV was quenched as a function of the Al(3+) concentration, confirming that DTMSPV is a cell-permeable fluorescent polymer that can function as a versatile probe to detect Al(3+) in living cells.-
dc.description.statementOfResponsibilityopen-
dc.format.extent3305~3311-
dc.relation.isPartOfACS APPLIED MATERIALS & INTERFACES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAluminum/analysis*-
dc.subject.MESHAnimals-
dc.subject.MESHCattle-
dc.subject.MESHElectrolytes/chemistry*-
dc.subject.MESHFluorescent Dyes/chemistry*-
dc.subject.MESHHumans-
dc.subject.MESHMesenchymal Stromal Cells/chemistry*-
dc.subject.MESHMesenchymal Stromal Cells/cytology*-
dc.subject.MESHProteins/chemistry*-
dc.subject.MESHSpectrometry, Fluorescence-
dc.subject.MESHSwine-
dc.titleHighly fluorescent conjugated polyelectrolyte for protein sensing and cell-compatible chemosensing applications-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학)-
dc.contributor.googleauthorJungmok You-
dc.contributor.googleauthorTeahoon Park-
dc.contributor.googleauthorJeonghun Kim-
dc.contributor.googleauthorJune Seok Heo-
dc.contributor.googleauthorHan-Soo Kim-
dc.contributor.googleauthorHyun Ok Kim-
dc.contributor.googleauthorEunkyoung Kim-
dc.identifier.doi10.1021/am500269t-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01100-
dc.contributor.localIdA01122-
dc.contributor.localIdA04367-
dc.relation.journalcodeJ00004-
dc.identifier.eissn1944-8252-
dc.identifier.pmid24527754-
dc.identifier.urlhttp://pubs.acs.org/doi/abs/10.1021/am500269t-
dc.subject.keywordcell imaging-
dc.subject.keywordchemosensing-
dc.subject.keywordconjugated polymer-
dc.subject.keywordprotein sensor-
dc.subject.keywordwater-soluble polymer-
dc.contributor.alternativeNameKim, Han Soo-
dc.contributor.alternativeNameKim, Hyun Ok-
dc.contributor.alternativeNameHeo, June Seok-
dc.contributor.affiliatedAuthorKim, Han Soo-
dc.contributor.affiliatedAuthorKim, Hyun Ok-
dc.contributor.affiliatedAuthorHeo, June Seok-
dc.rights.accessRightsfree-
dc.citation.volume6-
dc.citation.number5-
dc.citation.startPage3305-
dc.citation.endPage3311-
dc.identifier.bibliographicCitationACS APPLIED MATERIALS & INTERFACES, Vol.6(5) : 3305-3311, 2014-
dc.identifier.rimsid46125-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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