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이식신 계획생검 및 재생검에서 Kidney Injury Molecule-1 표현과 이식신 기능 변화
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김명수 | - |
dc.contributor.author | 김범석 | - |
dc.contributor.author | 김순일 | - |
dc.contributor.author | 김유선 | - |
dc.contributor.author | 이아란 | - |
dc.contributor.author | 정현주 | - |
dc.contributor.author | 주동진 | - |
dc.contributor.author | 허규하 | - |
dc.date.accessioned | 2015-12-28T11:04:59Z | - |
dc.date.available | 2015-12-28T11:04:59Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1298-1711 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138655 | - |
dc.description.abstract | Background : Kidney injury molecule-1 (KIM-1) is known as a good ancillary marker of acute kidney injury (AKI) and its expression has also been observed in acute rejection and chronic graft dysfunction. We tested usefulness of KIM-1 as an indicator of acute and chronic renal graft injury by correlating KIM-1 expression with renal graft function and histology. Methods : A total of 133 zero-time biopsies and 42 follow-up biopsies obtained within 1 year posttransplantation were selected. Renal tubular KIM-1 staining was graded semiquantitatively from 0 to 3 and the extent of staining was expressed as the ratio of KIM-1 positive/CD10 positive proximal tubules using Image J program. Results : KIM-1 was positive in 39.8% of zero-time biopsies. KIM-1 positive cases were predominantly male and had received grafts from donors with older age, deceased donors, and poor renal function at the time of donation, compared with KIM-1 negative cases. KIM-1 expression showed correlation with delayed graft function and acute tubular necrosis. In comparison of KIM-1 expression between stable grafts (n=23) and grafts with dysfunction (n=19) at the time of repeated biopsy, the intensity/extent of KIM-1 staining and renal histology at zero-time did not differ significantly between the two groups. Histologically, KIM-1 expression was significantly increased with both acute and chronic changes of glomeruli, tubules and interstitium, peritubular capillaritis, and arteriolar hyalinosis. Conclusions : KIM-1 can be used as an ancillary marker of AKI and a nonspecific indicator of acute inflammation and tubulointerstitial fibrosis. However, KIM-1 expression at zero-time is not suitable for prediction of long-term graft dysfunction. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 135~143 | - |
dc.language | Journal of the Korean Society for Transplantation | - |
dc.publisher | Journal of the Korean Society for Transplantation | - |
dc.relation.isPartOf | Journal of the Korean Society for Transplantation | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | 이식신 계획생검 및 재생검에서 Kidney Injury Molecule-1 표현과 이식신 기능 변화 | - |
dc.title.alternative | Changes of Kidney Injury Molecule-1 expression and renal allograft function in protocol and for cause renal allograft biopsy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | 김연희 | - |
dc.contributor.googleauthor | 이아란 | - |
dc.contributor.googleauthor | 김명수 | - |
dc.contributor.googleauthor | 주동진 | - |
dc.contributor.googleauthor | 김범석 | - |
dc.contributor.googleauthor | 허규하 | - |
dc.contributor.googleauthor | 김순일 | - |
dc.contributor.googleauthor | 김유선 | - |
dc.contributor.googleauthor | 정현주 | - |
dc.identifier.doi | 10.4285/jkstn.2014.28.3.135 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00488 | - |
dc.contributor.localId | A00649 | - |
dc.contributor.localId | A00785 | - |
dc.contributor.localId | A02945 | - |
dc.contributor.localId | A03771 | - |
dc.contributor.localId | A03948 | - |
dc.contributor.localId | A04344 | - |
dc.contributor.localId | A00424 | - |
dc.relation.journalcode | J01858 | - |
dc.identifier.eissn | 2508-2604 | - |
dc.subject.keyword | Kidney injury molecule-1 | - |
dc.subject.keyword | Acute kidney injury | - |
dc.subject.keyword | Graft dysfunction | - |
dc.subject.keyword | Histology | - |
dc.contributor.alternativeName | Kim, Myoung Soo | - |
dc.contributor.alternativeName | Kim, Beom Seok | - |
dc.contributor.alternativeName | Kim, Soon Il | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.alternativeName | Lee, A Lan | - |
dc.contributor.alternativeName | Jeong, Hyeon Joo | - |
dc.contributor.alternativeName | Joo, Dong Jin | - |
dc.contributor.alternativeName | Huh, Kyu Ha | - |
dc.contributor.affiliatedAuthor | Kim, Beom Seok | - |
dc.contributor.affiliatedAuthor | Kim, Soon Il | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Lee, A Lan | - |
dc.contributor.affiliatedAuthor | Jeong, Hyeon Joo | - |
dc.contributor.affiliatedAuthor | Joo, Dong Jin | - |
dc.contributor.affiliatedAuthor | Huh, Kyu Ha | - |
dc.contributor.affiliatedAuthor | Kim, Myoung Soo | - |
dc.citation.volume | 28 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 135 | - |
dc.citation.endPage | 143 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society for Transplantation, Vol.28(3) : 135-143, 2014 | - |
dc.identifier.rimsid | 38469 | - |
dc.type.rims | ART | - |
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