Cited 3 times in
Protease-activated receptor 2 activation inhibits N-type Ca2+ currents in rat peripheral sympathetic neurons.
DC Field | Value | Language |
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dc.contributor.author | 정승수 | - |
dc.contributor.author | 정지현 | - |
dc.contributor.author | 김영환 | - |
dc.contributor.author | 안덕선 | - |
dc.date.accessioned | 2015-12-28T11:04:02Z | - |
dc.date.available | 2015-12-28T11:04:02Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138621 | - |
dc.description.abstract | The protease-activated receptor (PAR)-2 is highly expressed in endothelial cells and vascular smooth muscle cells. It plays a crucial role in regulating blood pressure via the modulation of peripheral vascular tone. Although several mechanisms have been suggested to explain PAR-2-induced hypotension, the precise mechanism remains to be elucidated. To investigate this possibility, we investigated the effects of PAR-2 activation on N-type Ca(2+) currents (I(Ca-N)) in isolated neurons of the celiac ganglion (CG), which is involved in the sympathetic regulation of mesenteric artery vascular tone. PAR-2 agonists irreversibly diminished voltage-gated Ca(2+) currents (I(Ca)), measured using the patch-clamp method, in rat CG neurons, whereas thrombin had little effect on I(Ca). This PAR-2-induced inhibition was almost completely prevented by ω-CgTx, a potent N-type Ca(2+) channel blocker, suggesting the involvement of N-type Ca(2+) channels in PAR-2-induced inhibition. In addition, PAR-2 agonists inhibited I(Ca-N) in a voltage-independent manner in rat CG neurons. Moreover, PAR-2 agonists reduced action potential (AP) firing frequency as measured using the current-clamp method in rat CG neurons. This inhibition of AP firing induced by PAR-2 agonists was almost completely prevented by ω-CgTx, indicating that PAR-2 activation may regulate the membrane excitability of peripheral sympathetic neurons through modulation of N-type Ca(2+) channels. In conclusion, the present findings demonstrate that the activation of PAR-2 suppresses peripheral sympathetic outflow by modulating N-type Ca(2+) channel activity, which appears to be involved in PAR-2-induced hypotension, in peripheral sympathetic nerve terminals. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 804~811 | - |
dc.relation.isPartOf | MOLECULES AND CELLS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Action Potentials/drug effects | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Calcium Channels, N-Type/metabolism* | - |
dc.subject.MESH | Ganglia, Sympathetic/enzymology* | - |
dc.subject.MESH | Hypotension/metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mesenteric Arteries/physiology | - |
dc.subject.MESH | Neurons/metabolism | - |
dc.subject.MESH | Oligopeptides/pharmacology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Receptor, PAR-2/agonists | - |
dc.subject.MESH | Receptor, PAR-2/metabolism* | - |
dc.title | Protease-activated receptor 2 activation inhibits N-type Ca2+ currents in rat peripheral sympathetic neurons. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Physiology (생리학) | - |
dc.contributor.googleauthor | Young Hwan Kim | - |
dc.contributor.googleauthor | Duck Sun Ahn | - |
dc.contributor.googleauthor | Myeong Ok Kim | - |
dc.contributor.googleauthor | Ji Hyun Joeng | - |
dc.contributor.googleauthor | Seungsoo Chung | - |
dc.identifier.doi | 10.14348/molcells.2014.0167 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03643 | - |
dc.contributor.localId | A03737 | - |
dc.contributor.localId | A00732 | - |
dc.contributor.localId | A02223 | - |
dc.relation.journalcode | J02273 | - |
dc.identifier.eissn | 0219-1032 | - |
dc.identifier.pmid | 25410909 | - |
dc.subject.keyword | N-type Ca2+ channel | - |
dc.subject.keyword | celiac ganglion | - |
dc.subject.keyword | hypotension | - |
dc.subject.keyword | peripheral sympathetic output | - |
dc.subject.keyword | protease-activated receptor 2 | - |
dc.contributor.alternativeName | Chung, Seung Soo | - |
dc.contributor.alternativeName | Joeng, Ji Hyun | - |
dc.contributor.alternativeName | Kim, Young Hwan | - |
dc.contributor.alternativeName | Ahn, Duk Sun | - |
dc.contributor.affiliatedAuthor | Chung, Seung Soo | - |
dc.contributor.affiliatedAuthor | Joeng, Ji Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Young Hwan | - |
dc.contributor.affiliatedAuthor | Ahn, Duk Sun | - |
dc.citation.volume | 37 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 804 | - |
dc.citation.endPage | 811 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, Vol.37(11) : 804-811, 2014 | - |
dc.identifier.rimsid | 38450 | - |
dc.type.rims | ART | - |
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