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Effect of zoledronate on the expression of vascular endothelial growth factor-a by articular chondrocytes and synovial cells: an in vitro study.
DC Field | Value | Language |
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dc.contributor.author | 이우석 | - |
dc.date.accessioned | 2015-12-28T11:03:38Z | - |
dc.date.available | 2015-12-28T11:03:38Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 2287-6375 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138606 | - |
dc.description.abstract | BACKGROUND: The aim of this in vitro study was to determine the effect of zoledronate, which is frequently used to treat osteoporosis, on osteoarthritis by analyzing zoledronate-induced expression of vascular endothelial growth factor-A (VEGF-A) in chondrocytes and synovial cells. METHODS: After chondrocytes and synovial cells were separated and cultured, zoledronate was added, and VEGF-A and pigment epithelium-derived factor (PEDF) expression were quantified by real-time polymerase chain reaction and Western blotting. RESULTS: There was no significant difference in the expression of VEGF-A mRNA in chondrocytes between the zoledronate group and the control group on the 8th day of culture. The expression of both VEGF-A and PEDF mRNA in synovial cells was significantly decreased in the zoledronate group (P<0.05). CONCLUSIONS: Zoledronate decreases the expression of VEGF-A in synovial cells and may affect the development and progression of osteoarthritis. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 249~255 | - |
dc.relation.isPartOf | JBM : Journal of Bone Metabolism | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effect of zoledronate on the expression of vascular endothelial growth factor-a by articular chondrocytes and synovial cells: an in vitro study. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Orthopedic Surgery (정형외과학) | - |
dc.contributor.googleauthor | Jin Woong Yi | - |
dc.contributor.googleauthor | Woo Suk Lee | - |
dc.contributor.googleauthor | Sang Bum Kim | - |
dc.contributor.googleauthor | Youn Moo Heo | - |
dc.contributor.googleauthor | Dong Sik Chae | - |
dc.identifier.doi | 10.11005/jbm.2014.21.4.249 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02992 | - |
dc.relation.journalcode | J01214 | - |
dc.identifier.pmid | 25489573 | - |
dc.subject.keyword | Chondrocytes | - |
dc.subject.keyword | Osteoarthritis | - |
dc.subject.keyword | Synovial cells | - |
dc.subject.keyword | Vascular endothelial growth factor-A | - |
dc.subject.keyword | Zoledronate | - |
dc.contributor.alternativeName | Lee, Woo Suk | - |
dc.contributor.affiliatedAuthor | Lee, Woo Suk | - |
dc.citation.volume | 21 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 249 | - |
dc.citation.endPage | 255 | - |
dc.identifier.bibliographicCitation | JBM : Journal of Bone Metabolism, Vol.21(4) : 249-255, 2014 | - |
dc.identifier.rimsid | 38439 | - |
dc.type.rims | ART | - |
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