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Effect of zoledronate on the expression of vascular endothelial growth factor-a by articular chondrocytes and synovial cells: an in vitro study.

Authors
 Jin Woong Yi  ;  Woo Suk Lee  ;  Sang Bum Kim  ;  Youn Moo Heo  ;  Dong Sik Chae 
Citation
 JBM : Journal of Bone Metabolism, Vol.21(4) : 249-255, 2014 
Journal Title
 JBM : Journal of Bone Metabolism 
ISSN
 2287-6375 
Issue Date
2014
Keywords
Chondrocytes ; Osteoarthritis ; Synovial cells ; Vascular endothelial growth factor-A ; Zoledronate
Abstract
BACKGROUND: The aim of this in vitro study was to determine the effect of zoledronate, which is frequently used to treat osteoporosis, on osteoarthritis by analyzing zoledronate-induced expression of vascular endothelial growth factor-A (VEGF-A) in chondrocytes and synovial cells. METHODS: After chondrocytes and synovial cells were separated and cultured, zoledronate was added, and VEGF-A and pigment epithelium-derived factor (PEDF) expression were quantified by real-time polymerase chain reaction and Western blotting. RESULTS: There was no significant difference in the expression of VEGF-A mRNA in chondrocytes between the zoledronate group and the control group on the 8th day of culture. The expression of both VEGF-A and PEDF mRNA in synovial cells was significantly decreased in the zoledronate group (P<0.05). CONCLUSIONS: Zoledronate decreases the expression of VEGF-A in synovial cells and may affect the development and progression of osteoarthritis.
Files in This Item:
T201405064.pdf Download
DOI
10.11005/jbm.2014.21.4.249
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Woo Suk(이우석) ORCID logo https://orcid.org/0000-0002-0798-1660
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138606
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