247 388

Cited 9 times in

The glycated albumin to glycated hemoglobin ratio might not be associated with carotid atherosclerosis in patients with type 1 diabetes.

DC FieldValueLanguage
dc.contributor.author이병완-
dc.contributor.author이현철-
dc.contributor.author차봉수-
dc.contributor.author강은석-
dc.contributor.author김원진-
dc.contributor.author김광준-
dc.date.accessioned2015-12-28T11:03:12Z-
dc.date.available2015-12-28T11:03:12Z-
dc.date.issued2014-
dc.identifier.issn2233-6079-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138590-
dc.description.abstractBACKGROUND: The ratio of glycated albumin to glycated hemoglobin (GA/A1c) is known to be elevated in subjects with type 2 diabetes mellitus (T2DM) who had decreased insulin secretion. Additionally, the carotid intima media thickness (IMT) is greater in T2DM patients with higher GA/A1c ratios. We investigated whether increased GA/A1c ratio and IMT are also associated in type 1 diabetes mellitus (T1DM), which is characterized by lack of insulin secretory capacity. METHODS: In this cross-sectional study, we recruited 81 T1DM patients (33 men, 48 women; mean age 44.1±13.0 years) who underwent carotid IMT, GA, and HbA1c measurements. RESULTS: The mean GA/A1c ratio was 2.90. Based on these results, we classified the subjects into two groups: group I (GA/A1c ratio <2.90, n=36) and group II (GA/A1c ratio ≥2.90, n=45). Compared with group I, the body mass indexes (BMIs), waist circumferences, and IMTs were lower in group II. GA/A1c ratio was negatively correlated with BMI, urine albumin to creatinine ratio (P<0.001 for both), and both the mean and maximal IMT (P=0.001, both). However, after adjusting the confounding factors, we observed that IMT was no longer associated with GA/A1c ratio. CONCLUSION: In contrast to T2DM, IMT was not significantly related to GA/A1c ratio in the subjects with T1DM. This suggests that the correlations between GA/A1c ratio and the parameters known to be associated with atherosclerosis in T2DM could be manifested differently in T1DM. Further studies are needed to investigate these relationships in T1DM.-
dc.description.statementOfResponsibilityopen-
dc.format.extent456~463-
dc.relation.isPartOfDIABETES & METABOLISM JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe glycated albumin to glycated hemoglobin ratio might not be associated with carotid atherosclerosis in patients with type 1 diabetes.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorWonjin Kim-
dc.contributor.googleauthorKwang Joon Kim-
dc.contributor.googleauthorByung Wan Lee-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorBong Soo Cha-
dc.contributor.googleauthorHyun Chul Lee-
dc.identifier.doi10.4093/dmj.2014.38.6.456-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02796-
dc.contributor.localIdA03301-
dc.contributor.localIdA03996-
dc.contributor.localIdA00068-
dc.contributor.localIdA00772-
dc.contributor.localIdA00317-
dc.relation.journalcodeJ00720-
dc.identifier.eissn2233-6087-
dc.identifier.pmid25541609-
dc.subject.keywordCarotid intima-media thickness-
dc.subject.keywordDiabetes mellitus, type 1-
dc.subject.keywordGlycated albumin to glycated hemoglobin ratio-
dc.subject.keywordGlycosylated serum albumin-
dc.contributor.alternativeNameLee, Byung Wan-
dc.contributor.alternativeNameLee, Hyun Chul-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKim, Won Jin-
dc.contributor.affiliatedAuthorLee, Byung Wan-
dc.contributor.affiliatedAuthorLee, Hyun Chul-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorKim, Won Jin-
dc.contributor.affiliatedAuthorKim, Kwang Joon-
dc.citation.volume38-
dc.citation.number6-
dc.citation.startPage456-
dc.citation.endPage463-
dc.identifier.bibliographicCitationDIABETES & METABOLISM JOURNAL, Vol.38(6) : 456-463, 2014-
dc.identifier.rimsid38425-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.